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Head-to-head evidence comparison — which supplement is right for you?
Aged Garlic Extract wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
13 of 14 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mixed evidence
1 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Aged Garlic Extract and DHM have evidence — compare verdict strength side-by-side.
600-1200mg aged garlic extract
With meals, Split into 2 doses
Kyolic Aged Garlic Extract (most studied)
300-600mg before or after drinking; 300mg daily for liver support
Before drinking alcohol, Before bed after drinking, Daily for liver support
Dihydromyricetin capsules or tablets
8-12 weeks
12+ weeks
4-8 weeks
Acute
Acute and ongoing
Next day
Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials
Prostaglandins & other lipid mediators (2024) · Meta analysis · n=584
AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: -4.03; %95CI: -6.87, -1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: -1.44; 95 % CI= -2.87, -0.02; P = 0.052; I2: 36.8 %; P: 0.105).
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis
Phytotherapy research : PTR (2023) · Meta analysis
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Journal of the science of food and agriculture (2012) · Meta analysis · n=26
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention
Cell proliferation (2023) · Systematic review
This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.
Flavonoids-mediated SIRT1 signaling activation in hepatic disorders
Life sciences (2020) · Systematic review
Additionally, molecular modeling simulations were applied to explore the potential binding mode of these flavonoids to SIRT1.
Metabolic mechanisms of Dihydromyricetin and strategies for enhancing its bioavailability: A recent review
Food chemistry (2025) · Systematic review
It examines the key factors influencing its bioavailability and highlights the design and construction of various bio-based delivery systems aimed at improving its bioavailability.
Meta-analysis shows modest SBP reduction of ~4 mmHg and DBP reduction of ~1.4 mmHg. Effect size is relatively small compared to pharmaceutical interventions. Studies primarily used aged garlic extract forms.
Evidence primarily from systematic reviews examining polyphenol hepatoprotective mechanisms rather than direct DHM clinical trials. Bioavailability limitations may reduce actual effectiveness. Conservative estimates given lack of specific dose-response studies.
AI-estimated from published studies. Interpret as directional guidance.
Aged Garlic Extract has a higher evidence score (9/10 vs 7.5/10) and wins in 2 of 3 categories.
For reduce inflammation, Aged Garlic Extract has a higher relevance score (90 vs 75).
No known interactions between Aged Garlic Extract and DHM have been documented in our database. However, always consult a healthcare provider before combining supplements.