Fadogia Agrestis
Nigerian shrub with preliminary evidence for testosterone and libido support — popular but human research is still very limited.
Fadogia Agrestis is a shrub native to Nigeria traditionally used as an aphrodisiac and for treating erectile dysfunction. It has gained significant popularity in the fitness community for potential testosterone-boosting effects. However, research is very limited - primarily animal studies - and there are potential safety concerns that warrant caution.
May increase testosterone in animal studies
Traditional aphrodisiac use
How Fadogia Agrestis works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
300-600mg extract daily
Loading: Not established; start conservative
Take with food
| Form | Type |
|---|---|
| 💊Standardized extract | Recommended |
| 💊Capsules | Alternative |
Quality varies significantly. Choose reputable sources with third-party testing.
Minimum: 2 weeks
Optimal: 8 weeks
Cycling: Strong recommendation to cycle: 4-6 weeks on, 4 weeks off
Note: Limited dosing guidance. Conservative approach recommended given limited safety data.
May increase testosterone (animal data only)
Traditional use for sexual function
Animal studies show potential testicular toxicity at high doses
Exercise caution - limited human safety data
May interfere with hormone replacement; consult endocrinologist
May affect hormonal balance; use with caution
May affect blood sugar levels; monitor glucose
Tip: Cycle use; stay within recommended doses
Top studies from 4+ peer-reviewed papers
Ogunro OB et al. • Reproductive sciences (Thousand Oaks, Calif.) (2023)
“The Author(s), under exclusive licence to Society for Reproductive Investigation.”
Clemesha CG et al. • International Journal of Impotence Research (2022)
“There is currently no human clinical trial data supporting Fadogia agrestis for testosterone enhancement; all evidence is derived from rat studies.”
van Andel T et al. • Journal of ethnopharmacology (2012)
“Our quantitative market survey reveals that the trade in Ghanaian herbal medicine is of considerable economic importance.”
Yakubu MT et al. • Asian Journal of Andrology (2005)
“Fadogia agrestis extract increased testosterone levels in rats but also caused dose-dependent changes in testicular tissue.”
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