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Oxiracetam
Racetam nootropic that sharpens memory formation, logical thinking, and verbal fluency with mild stimulant effects — best paired with choline.
What the evidence says
Oxiracetam appears to help in 4 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2010–2026 with a typical study size of 1,856 participants.
Based on 11 studies · 4 meta-analyses · 5 RCTs · 49,934 total participants
Confidence
HighWhat the studies found
By outcome
Oxiracetam has an evidence score of 7/10 — strong evidence based on 11 indexed studies, including 4 meta-analyses. Racetam nootropic that sharpens memory formation, logical thinking, and verbal fluency with mild stimulant effects — best paired with choline.
The commonly studied dose of Oxiracetam is 800-2400mg daily in divided doses. Research points to an estimated optimal dose around 1600mg, with a minimum effective dose near 800mg. Individual response varies — start low and adjust.
The best time to take Oxiracetam is in the morning. Taking it with food is preferred. Oxiracetam is a water-soluble racetam nootropic that modulates AMPA and cholinergic neurotransmission.
Last reviewed May 2026 · evidence from 14 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Oxiracetam is a racetam nootropic developed in the 1970s that is more potent than piracetam. It's known for enhancing memory formation, learning capacity, and logical thinking. Users often report improved verbal fluency and clearer thinking. It has mild stimulant properties without the jitteriness of caffeine. Like other racetams, it works best when combined with a choline source.
Positive modulator of AMPA receptors
Increases acetylcholine utilization
Subtle energizing effect
How Oxiracetam works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
800-2400mg daily in divided doses
Loading: Not required; effects build over 1-2 weeks
Can be taken without food
| Form | Type |
|---|---|
| 💊Oxiracetam powder or capsules | Recommended |
Available as powder (economical) or capsules. Has slightly bitter taste.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: 8-12 weeks on, 2-4 weeks off
Note: Mild stimulant effect - avoid evening doses. Water-soluble and well-absorbed. Combine with Alpha-GPC or CDP-Choline.
Based on multiple meta-analyses showing cognitive improvements in vascular dementia and stroke populations. One major RCT (n=500) showed no benefit for post-stroke cognitive impairment, limiting confidence. Effects may be population-specific and less pronounced in healthy individuals.
Improved memory formation and recall
Enhanced analytical and logical processes
Improved word recall and articulation
Without adequate choline
Popular for studying and analytical work
May have anticoagulant effects; use caution with blood thinners
Has mild stimulant properties; may be additive with other stimulants
May counteract anticholinergic effects as racetams enhance acetylcholine
Tip: Take with choline source
Tip: Avoid evening doses
Tip: Reduce dose
Oxiracetam is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are headache, insomnia, nervousness. Use caution if any of these apply to you: Severe kidney impairment.
Piracetam
Likely helpsFirst-ever nootropic (1972) that improves membrane fluidity and AMPA receptor function — decades of safety data for cognitive enhancement.
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