Oxiracetam
Racetam nootropic that sharpens memory formation, logical thinking, and verbal fluency with mild stimulant effects — best paired with choline.
Oxiracetam is a racetam nootropic developed in the 1970s that is more potent than piracetam. It's known for enhancing memory formation, learning capacity, and logical thinking. Users often report improved verbal fluency and clearer thinking. It has mild stimulant properties without the jitteriness of caffeine. Like other racetams, it works best when combined with a choline source.
Positive modulator of AMPA receptors
Increases acetylcholine utilization
Subtle energizing effect
How Oxiracetam works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
800-2400mg daily in divided doses
Loading: Not required; effects build over 1-2 weeks
Can be taken without food
| Form | Type |
|---|---|
| 💊Oxiracetam powder or capsules | Recommended |
Available as powder (economical) or capsules. Has slightly bitter taste.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: 8-12 weeks on, 2-4 weeks off
Note: Mild stimulant effect - avoid evening doses. Water-soluble and well-absorbed. Combine with Alpha-GPC or CDP-Choline.
Improved memory formation and recall
Enhanced analytical and logical processes
Improved word recall and articulation
Without adequate choline
Popular for studying and analytical work
May have anticoagulant effects; use caution with blood thinners
Has mild stimulant properties; may be additive with other stimulants
May counteract anticholinergic effects as racetams enhance acetylcholine
Tip: Take with choline source
Tip: Avoid evening doses
Tip: Reduce dose
Top studies from 14+ peer-reviewed papers
Wang B et al. • Pakistan journal of pharmaceutical sciences (2020)
“The clinical effect is definite.”
Yi Z et al. • Journal of nanoscience and nanotechnology (2020)
“Based on the current clinical evidence, olacetam is more effective and safer than alternatives in the treatment of vascular cognitive dysfunction.”
Perng CH et al. • Psychopharmacology (2018)
“The most effective intervention for dementia available is symptomatic treatment for vascular dementia.”
Lim JS et al. • European stroke journal (2026)
“Oxiracetam did not demonstrate benefit in preventing PSCI in high-risk patients.”
Zhang T et al. • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2024)
“(S)-oxiracetam was safe and tolerated with favorable pharmacokinetic profiles at all study doses, providing dosing evidence for further efficacy evaluation.”
What would you like to do next?
Citicoline
8.5/10Dual precursor to acetylcholine and phosphatidylcholine — enhances memory, focus, and brain cell membrane repair.
Caffeine
9.5/10Blocks adenosine receptors to boost alertness, reaction time, and endurance — one of the most proven ergogenic aids.
Piracetam
9/10First-ever nootropic (1972) that improves membrane fluidity and AMPA receptor function — decades of safety data for cognitive enhancement.
Alpha-GPC
8.5/10Crosses the blood-brain barrier to fuel acetylcholine synthesis — supports focus, memory, and power output in athletes.
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