Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Aged Garlic Extract wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
14 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Agarikon and Aged Garlic Extract have evidence — compare verdict strength side-by-side.
500-1500mg extract daily
With or without food
Agarikon extract
600-1200mg aged garlic extract
With meals, Split into 2 doses
Kyolic Aged Garlic Extract (most studied)
4-8 weeks
Ongoing
N/A
8-12 weeks
12+ weeks
4-8 weeks
Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties
Chemistry & biodiversity (2020) · Systematic review
Because of its valuable biological properties and its use in 18th and 19th-century pharmacy, Fomitopsis officinalis used to be mass-collected.
An antitumor fungal polysaccharide from Fomitopsis officinalis by activating immunity and inhibiting angiogenesis
International journal of biological macromolecules (2024) · Observational
The following mechanism examination discovered that FOBP50-1 interacted with TLR-4, PD-1, and VEGF to activate immunity and inhibit angiogenesis according to a series of cell, transgenic zebrafish, and surface plasmon resonance (SPR) experiments.
A fungal polysaccharide from Fomitopsis officinalis as a multi-target molecule to combat cancer
International journal of biological macromolecules (2024) · Observational
The following mechanistic analysis discovered that the in vivo antitumor effect was linked to immune activation and angiogenesis inhibition.
Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials
Prostaglandins & other lipid mediators (2024) · Meta analysis · n=584
AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: -4.03; %95CI: -6.87, -1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: -1.44; 95 % CI= -2.87, -0.02; P = 0.052; I2: 36.8 %; P: 0.105).
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis
Phytotherapy research : PTR (2023) · Meta analysis
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Journal of the science of food and agriculture (2012) · Meta analysis · n=26
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
Evidence primarily from animal studies and in-vitro research. Polysaccharide compounds show immunomodulatory activity through TLR-4 interactions. Human clinical data limited. Conservative estimates due to lack of RCT data.
Meta-analysis shows modest SBP reduction of ~4 mmHg and DBP reduction of ~1.4 mmHg. Effect size is relatively small compared to pharmaceutical interventions. Studies primarily used aged garlic extract forms.
AI-estimated from published studies. Interpret as directional guidance.
Aged Garlic Extract has a higher evidence score (7.5/10 vs 3.5/10) and wins in 3 of 3 categories.
For reduce inflammation, Aged Garlic Extract has a higher relevance score (90 vs 45).
No known interactions between Agarikon and Aged Garlic Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.