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Head-to-head evidence comparison — which supplement is right for you?
Aged Garlic Extract vs L-Lysine: Aged Garlic Extract has the stronger overall evidence (7.5 vs 5.5/10); they're alternatives for support immune system — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Aged Garlic Extract wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
11 of 12 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
6 of 8 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Aged Garlic Extract and L-Lysine have evidence — compare verdict strength side-by-side.
600-960mg aged garlic extract — range pending qualified review, and not scoped to a formulation, population, duration or outcome
With meals, Split into 2 doses
Kyolic Aged Garlic Extract (most studied)
500-3000mg daily; higher for active outbreaks
Empty stomach for better absorption, Divided doses throughout day, Away from high-arginine foods
L-Lysine HCl (capsules or powder)
8-12 weeks
12+ weeks
4-8 weeks
2-4 weeks prevention; acute treatment faster
4-8 weeks
Ongoing
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis
Phytotherapy research : PTR (2023) · Meta analysis
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Journal of the science of food and agriculture (2012) · Meta analysis · n=26
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins
The American journal of clinical nutrition (2006) · Rct · n=3411
Regressions adjusted for covariates indicated increases of 0.22 mmol total cholesterol/L (P = 0.01) and 0.19 mmol LDL/L (P = 0.02) after 7.3 y of micronutrient supplementation, but no effect of garlic supplementation or short-term amoxicillin and omeprazole treatment.
The Impact of Amino Acids on Postprandial Glucose and Insulin Kinetics in Humans: A Quantitative Overview
Nutrients (2020) · Systematic review · n=55
Oral ingestion of most individual AAs induced an insulin response, but did not alter glucose concentrations in healthy participants.
Nutraceuticals and phytoceuticals in the treatment of schizophrenia: a systematic review and network meta-analysis "Nutra NMA SCZ"
Molecular psychiatry (2025) · Meta analysis · n=50
Change (Standardized Mean Difference = SMD) in total symptomatology and acceptability (Risk Ratio = RR) were co-primary outcomes.
A Dietary Supplement in the Management of Patients with Lumbar Osteochondrosis: A Randomized, Double-Blinded, Placebo-Controlled Study
Nutrients (2024) · Rct
Despite no significance regarding the distribution of Pfirrmann grade changes (improvement, no change, worsening; p = 0.259), in the supplement group, one patient achieved a three-grade improvement, and worsening of Pfirrmann grades were only detected in the placebo group (9.1%).
Retraction repair (2026-09-03). Everything this curve asserted above the studied range came from the 2024 meta-analysis that has since been retracted (PMID 39437887): its subgroup claim of a benefit threshold ABOVE every dose the surviving trials tested was the sole support for this curve's three highest points and for its former optimum, so those points and that optimum are removed rather than re-estimated, and the claim is not repeated here. NO OPTIMAL DOSE IS ASSERTED IN ITS PLACE. The only randomised dose COMPARISON left in this entry runs the other way: Ried 2013 (n=79), a dose-response trial, found 480 mg/day lowered systolic pressure by 11.8 mmHg (p=0.006) while its own 960 mg/day arm reached only 7.4 mmHg (p=0.07), with tolerability best at the one- and two-capsule doses. Ried 2010 (n=50) found 10.2 mmHg at 960 mg/day, but that is a different trial, not evidence that 960 beats 480. A 2023 triple-blind trial added on top of drug therapy found about 2 mmHg. So the remaining evidence does not describe a dose-response shape at all, and the sweet-spot marker stays off the chart until a clinician rules on it. minimumEffectiveDose 480 is the lowest dose at which a randomised arm in this entry showed a significant reduction; it is a cited dose, not a shape. No maxSafeDose is asserted on this curve: the field is null. ⚠️ An earlier version of this note described a stored 2400 as "unverified and left in place" — that value was removed on 2026-09-06 and the sentence outlived it, so a reader was told about a ceiling that no longer existed. The account of why no ceiling is stated lives in safety.maxSafeDose and is not repeated here. Confidence is downgraded to low: no pooled estimate survives.
Safety profile based on systematic review of 71 studies (n=2619). Risk analysis showed no statistically significant increase in GI symptoms (RR 1.02, 95% CI 0.96-1.07, p=0.49). Adverse events were mainly subjective GI symptoms. Short-term use up to 6g appears safe.
AI-estimated from published studies. Interpret as directional guidance.
Aged Garlic Extract has a higher evidence score (7.5/10 vs 5.5/10) and wins in 2 of 3 categories.
Both Aged Garlic Extract and L-Lysine score equally (70) for support immune system.
No known interactions between Aged Garlic Extract and L-Lysine have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.