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Head-to-head evidence comparison — which supplement is right for you?
Andrographis wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Probably helps
4 of 8 studies with measurable effects showed benefit.
Top outcomes
200-400mg standardized extract daily (e.g. CVT-E002 for immune use); 1-3g root for glycemic use, taken before meals
morning
Polysaccharide-standardized extract (immune) or root (glycemic)
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
2-16 weeks
4-12 weeks
2-8 weeks
2-5 days
2-5 days
2-5 days
Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies.
Journal of evidence-based complementary & alternative medicine (2017) · Systematic review
North American ginseng listed among herbals found effective for respiratory illness
Complementary and alternative medicine for prevention and treatment of the common cold.
Canadian family physician Medecin de famille canadien (2011) · Systematic review
North American ginseng among reviewed cold-prevention options
Ginseng as a Treatment for Fatigue: A Systematic Review.
Journal of alternative and complementary medicine (New York, N.Y.) (2018) · Systematic review
Modest evidence for efficacy across 10 reviewed studies
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis · n=1000
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Based on RCT showing significant improvement in cough (SMD -0.39) and sore throat symptoms. Conservative effectiveness estimates due to moderate effect sizes in meta-analysis of respiratory infections.
AI-estimated from published studies. Interpret as directional guidance.
Andrographis has a higher evidence score (7/10 vs 5.2/10) and wins in 2 of 3 categories.
For support immune system, Andrographis has a higher relevance score (90 vs 62).
No known interactions between American Ginseng and Andrographis have been documented in our database. However, always consult a healthcare provider before combining supplements.