Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Andrographis and Cat's Claw are closely matched across evidence, studies, and safety.
Verdict
Probably helps
4 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mixed evidence
1 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Andrographis and Cat's Claw have evidence — compare verdict strength side-by-side.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
250-350mg standardized extract or 1-3g dried bark, 2-3x daily
With meals
Standardized extract (3% oxindole alkaloids)
2-5 days
2-5 days
2-5 days
4-8 weeks
2-4 weeks
4-8 weeks
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis · n=1000
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Uncaria tomentosa as a Promising Natural Source of Molecules with Multiple Activities: Review of Its Ethnomedicinal Uses, Phytochemistry and Pharmacology
International journal of molecular sciences (2025) · Systematic review
The present paper reviews research progress relating to the ethnobotany, phytochemistry and pharmacology of Ut, and some promising research routes are also discussed.
Systemic therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer
The Cochrane database of systematic reviews (2022) · Meta analysis · n=137
The two studies, investigating vitamin D and omega-3 fatty acids, showed a treatment effect with 95% CIs that did not include an MCID for pain.
Bioactive Molecules from Tropical American Plants: Potential Anti-Inflammatory Agents for Cytokine Storm Management
Molecules (Basel, Switzerland) (2025) · Systematic review
Key polyphenols, like quercetin and luteolin, found in plants such as Achyrocline satureioides and Mangifera indica demonstrate the downregulation of NF-κB and inhibition of pro-inflammatory cytokines.
Based on RCT showing significant improvement in cough (SMD -0.39) and sore throat symptoms. Conservative effectiveness estimates due to moderate effect sizes in meta-analysis of respiratory infections.
Based on systematic review evidence showing significant pain reduction in knee osteoarthritis. Limited number of direct RCTs. Most studies used 250-350mg doses. GI upset more common at higher doses.
AI-estimated from published studies. Interpret as directional guidance.
Both Andrographis and Cat's Claw are closely matched — the best choice depends on your specific health goals.
For support immune system, Andrographis has a higher relevance score (90 vs 70).
No known interactions between Andrographis and Cat's Claw have been documented in our database. However, always consult a healthcare provider before combining supplements.