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Head-to-head evidence comparison — which supplement is right for you?
Omega-3 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
4 of 7 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
15 of 23 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Andrographis and Omega-3 have evidence — compare verdict strength side-by-side.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
2-3g combined EPA+DHA daily
With meals containing fat
Triglyceride form fish oil
2-5 days
2-5 days
2-5 days
4-8 weeks
2-4 weeks
Immediate
4-12 weeks
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis · n=1000
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial
Nature communications (2025) · Meta analysis · n=5205
Mean body mass index (BMI) was 27.5 kg/m2 (SD = 5.3), with 51% female and 17% Black race/ethnicity.
Omega-3 fatty acids for intermittent claudication
The Cochrane database of systematic reviews (2024) · Meta analysis · n=1830
Omega-3 compared with a control may have little to no effect on ankle-brachial index (MD -0.02, 95% CI -0.08 to 0.04; 3 studies, 168 participants; very low-certainty evidence).
A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)
Nutritional neuroscience (2024) · Meta analysis · n=587
The present systematic review and meta-analysis indicate the efficacy of omega-3 FAs in increasing the serum concentration of BDNF.
Based on RCT showing significant improvement in cough (SMD -0.39) and sore throat symptoms. Conservative effectiveness estimates due to moderate effect sizes in meta-analysis of respiratory infections.
Based on multiple meta-analyses showing EPA-dominant formulas >1g/day most effective. Effects plateau around 2-2.5g. Adjunctive use with antidepressants shows better outcomes than monotherapy.
AI-estimated from published studies. Interpret as directional guidance.
Omega-3 has a higher evidence score (9/10 vs 8.5/10) and wins in 3 of 3 categories.
For reduce inflammation, Omega-3 has a higher relevance score (90 vs 70).
No known interactions between Andrographis and Omega-3 have been documented in our database. However, always consult a healthcare provider before combining supplements.