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Head-to-head evidence comparison — which supplement is right for you?
Apigenin vs Black Cohosh: Black Cohosh has the stronger overall evidence (5 vs 4/10); they're alternatives for menopause support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Black Cohosh wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
3 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
7 of 10 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Apigenin and Black Cohosh have evidence — compare verdict strength side-by-side.
50mg before bed
30-60 minutes before bed
Apigenin extract capsules
20-40mg standardized extract (1mg triterpene glycosides)
Morning and evening, With or without food
Standardized extract (2.5% triterpene glycosides)
30-60 minutes
30-60 minutes
N/A
4-8 weeks
4-8 weeks
4-8 weeks
Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation
Renal failure (2025) · Meta analysis · n=1443
Meanwhile, when the treatment duration exceeds 12 weeks, AS demonstrated a significant reduction in fasting blood glucose levels, indicating a time-dependent effect.
Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives
CNS neuroscience & therapeutics (2025) · Systematic review
Although levodopa is indispensable for the symptomatic management of PD, emerging evidence supports the integration of plant-derived bioactive compounds as adjunct therapies with disease-modifying potential.
Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies
Nutrients (2018) · Meta analysis · n=12
High intake of dietary flavonols, flavones and anthocyanidins may decrease the risk of colorectal cancer; the pooled odds ratio (OR) for the highest intake compared with the lowest was 0.70 (0.54⁻0.90), 0.79 (0.83⁻0.99) and 0.78 (0.64⁻0.95), respectively.
Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis
Menopause (New York, N.Y.) (2023) · Meta analysis · n=2310
However, black cohosh did not significantly improve anxiety (Hedges' g = 0.194, 95% CI = -0.296 to 0.684, P = 0.438) or depressive symptoms (Hedges' g = 0.406, 95% CI = -0.121 to 0.932, P = 0.131).
Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials
Nutritional neuroscience (2022) · Systematic review
For most phytonutrients, the effects of supplementation on HPA-axis activity in humans is unclear.
Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence
Climacteric : the journal of the International Menopause Society (2021) · Meta analysis · n=43759
Effect sizes were larger when higher dosages of iCR as monotherapy or in combination with St.
Based on preclinical studies showing neuroinflammation inhibition and lung injury models. Human clinical data lacking. Effects may vary significantly based on bioavailability and individual response.
Based on multiple meta-analyses showing modest improvement in hot flashes. Isopropanolic extracts (iCR) showed most consistent effects. Effect sizes were larger at higher dosages but evidence shows only moderate benefit overall.
AI-estimated from published studies. Interpret as directional guidance.
Black Cohosh has a higher evidence score (5/10 vs 4/10) and wins in 2 of 3 categories.
For menopause support, Black Cohosh has a higher relevance score (58 vs 50).
No known interactions between Apigenin and Black Cohosh have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.