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Head-to-head evidence comparison — which supplement is right for you?
B-Complex vs Vitex: B-Complex has the stronger overall evidence (6.5 vs 7/10); they're alternatives for testosterone & cortisol symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
B-Complex wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
5 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
11 of 12 studies with measurable effects showed benefit.
Top outcomes
1 capsule daily (per label)
Morning with breakfast
Methylated B-complex (methylcobalamin, methylfolate)
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
and 1 more not shown
2-4 weeks
4-8 weeks
Immediate
1-3 cycles
2-3 cycles
1-2 cycles
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2024) · Meta analysis · n=42768
The meta-analysis on the effects of folate-based B vitamin supplementation on cognitive function showed a significant overall impact (Z = 3.84; p = 0.0001; SMD, 0.18; 95% CI, 0.09, 0.28).
A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals
Nutrients (2019) · Meta analysis · n=2015
Regarding individual facets of mood, B vitamin supplementation benefited stress (n = 958, SMD = 0.23, 95% CI = 0.02, 0.45, p = 0.03).
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Meta analysis
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Multiple meta-analyses show small but statistically significant benefits for cognitive function in older adults and stroke prevention populations. Effect sizes are modest (SMD ~0.15-0.18). Benefits may be more pronounced in B-vitamin deficient populations.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
B-Complex has a higher evidence score (6.5/10 vs 7/10) and wins in 2 of 3 categories.
For testosterone & cortisol symptoms, Vitex has a higher relevance score (92 vs 50).
No known interactions between B-Complex and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.
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The transition years (40s): cycle changes, mood, sleep, brain fog — foundations, vitex, and starting muscle work early.
When to take what, with or without food, and which supplements compete vs pair well.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.