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Head-to-head evidence comparison — which supplement is right for you?
Benfotiamine vs CoQ10: CoQ10 has the stronger overall evidence (8 vs 5.5/10); they're alternatives for metabolic health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
CoQ10 wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
2 of 2 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
9 of 10 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Benfotiamine and CoQ10 have evidence — compare verdict strength side-by-side.
150-600mg daily
With meals
Benfotiamine capsules
100-300mg daily
With fatty meal
Ubiquinol (reduced form)
4-12 weeks
8-12 weeks
4-12 weeks
8-12 weeks
4-8 weeks
2-8 weeks
Vitamin B and its derivatives for diabetic kidney disease
The Cochrane database of systematic reviews (2015) · Meta analysis · n=1354
There is an absence of evidence to recommend the use of vitamin B therapy alone or combination for delaying progression of DKD.
Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
BMJ open (2022) · Meta analysis · n=364
Meta-analysis of 6 trials in 364 adults with type 2 diabetes given 100 to 900 mg a day of thiamine or benfotiamine for up to 3 months.
Therapeutic potential of benfotiamine and its molecular targets
European review for medical and pharmacological sciences (2018) · Systematic review
The reduction in AGEs subsequently decreases metabolic stress which benefits vascular complications seen in diabetes.
Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
Reproductive sciences (Thousand Oaks, Calif.) (2023) · Meta analysis · n=1021
Meta-analysis of 9 randomised trials with 1,021 women with polycystic ovary syndrome.
Coenzyme Q10 for heart failure
The Cochrane database of systematic reviews (2021) · Meta analysis · n=1573
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
Antioxidants for female subfertility
The Cochrane database of systematic reviews (2017) · Meta analysis · n=6510
This suggests that among subfertile women with an expected clinical pregnancy rate of 22%, the rate among women using antioxidants would be between 27% and 33%.
The points come from one dose-comparison trial, BENDIP (PMID 18473286): 165 people with diabetic polyneuropathy randomised to 300 mg, 600 mg or placebo for 6 weeks, 133 in the ITT analysis. The Neuropathy Symptom Score differed between groups in the per-protocol analysis (p=0.033) but only narrowly missed significance by intention to treat (p=0.055), and the Total Symptom Score did not differ. Improvement was more pronounced at 600 mg, and both doses were well tolerated. No higher dose was compared, so no optimal dose can be given. The minimum effective dose comes from a separate 3-week trial of 400 mg a day in 40 inpatients, where the neuropathy score and pain improved against placebo (PMID 15726875). At 300 mg a day for 24 months, a trial in 67 people with type 1 diabetes found no effect on peripheral nerve function (PMID 22446172).
AI-estimated from published studies. Interpret as directional guidance.
CoQ10 has a higher evidence score (8/10 vs 5.5/10) and wins in 2 of 3 categories.
For metabolic health, CoQ10 has a higher relevance score (75 vs 65).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.