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Head-to-head evidence comparison — which supplement is right for you?
Benfotiamine vs Potassium: Benfotiamine has the stronger overall evidence (5.5 vs 8.5/10); they're alternatives for reduce inflammation — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Benfotiamine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
7 of 7 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
5 of 8 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Benfotiamine and Potassium have evidence — compare verdict strength side-by-side.
150-600mg daily
With meals
Benfotiamine capsules
99-500mg daily from supplements (food provides more)
With food to reduce GI upset, Spread throughout day, During/after exercise for athletes
Potassium Citrate or Potassium Gluconate
and 10 more not shown
4-12 weeks
8-12 weeks
2-4 weeks
1-2 weeks
Long-term
With excess or kidney issues
Vitamin B and its derivatives for diabetic kidney disease
The Cochrane database of systematic reviews (2015) · Meta analysis · n=1354
There is an absence of evidence to recommend the use of vitamin B therapy alone or combination for delaying progression of DKD.
Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
BMJ open (2022) · Meta analysis · n=364
There was a significant increase in high-density lipoprotein (HDL) (MD, 0.10; 95% CI: 0.10 to 0.20) at 3-month follow-up.
Therapeutic potential of benfotiamine and its molecular targets
European review for medical and pharmacological sciences (2018) · Systematic review
The reduction in AGEs subsequently decreases metabolic stress which benefits vascular complications seen in diabetes.
Effect of changes in potassium intake on blood pressure: a dose–response meta-analysis of randomized clinical trials (2000–2024)
Clinical Kidney Journal (2025) · Meta analysis · n=2500
Dose-response analysis of RCTs from 2000-2024
Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length
Nutrients (2024) · Meta analysis
Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations.
Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies
BMC medicine (2024) · Meta analysis · n=237036
Meta-analysis examining Potassium efficacy
Limited RCT data with mixed results. Meta-analysis found insufficient evidence to determine clear benefit. Conservative estimates based on subset of positive trials showing modest improvements in neuropathic symptoms.
AI-estimated from published studies. Interpret as directional guidance.
Benfotiamine has a higher evidence score (5.5/10 vs 8.5/10) and wins in 2 of 3 categories.
For reduce inflammation, Potassium has a higher relevance score (85 vs 75).
No known interactions between Benfotiamine and Potassium have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.