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Head-to-head evidence comparison — which supplement is right for you?
Bimatoprost (lashes) wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Prescription topical. Bimatoprost 0.03% is applied once daily as a thin line to the skin of the UPPER eyelid margin at the lash base (not to the lower lid, and avoid getting it in the eye), using a fresh applicator per eye. Continuous use is needed to maintain results. Use under a clinician, especially if you have glaucoma or take prostaglandin eye drops. There is no oral or systemic use. This library does not provide an ingestion protocol.
evening
Bimatoprost 0.03% solution (Latisse) with single-use applicators, under a clinician
Topical cosmetic only. Centella/cica is used in serums, creams, and balms (often standardized to madecassoside/asiaticoside) applied to clean skin once or twice daily, popular for soothing and post-procedure care. There is no oral, injectable, or systemic dose in this cosmetic context — oral gotu kola is separate. This library does not provide an ingestion protocol.
any
Leave-on serum, cream, or balm standardized to centella triterpenes
Throughout
8-16 weeks
2-6 months after stopping
Weeks to months
Throughout
2-8 weeks
1-4 weeks
12-24 weeks
Long-term safety and efficacy of bimatoprost solution 0.03% application to the eyelid margin for the treatment of idiopathic and chemotherapy-induced eyelash hypotrichosis: a randomized controlled trial.
Br J Dermatol (2015) · Rct
1-year double-masked RCT: composite primary endpoint (Global Eyelash Assessment + satisfaction) met for bimatoprost vs vehicle in idiopathic (40.2% vs 6.8%) and post-chemotherapy (37.5% vs 18.2%) hypotrichosis
Bimatoprost for eyelash growth in Japanese subjects: two multicenter controlled studies.
Aesthetic Plast Surg (2014) · Rct · n=209
Two double-masked vehicle-controlled RCTs (n=209: 173 idiopathic, 36 chemotherapy-induced) in Japanese subjects
The efficacy of topical prostaglandin analogs for hair loss: A systematic review and meta-analysis.
Front Med (Lausanne) (2023) · Meta analysis
Meta-analysis of six placebo-controlled RCTs of topical prostaglandin analogs (incl. bimatoprost) for hair growth (lashes, brows, scalp)
Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.
Exp Dermatol (2008) · Rct · n=20
Randomized double-blind study (n=20) of topical 5% vitamin C + 0.1% madecassoside on photoaged skin over 6 months
Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds.
J Drugs Dermatol (2025) · Rct · n=60
RCT (n=60) after cryotherapy for actinic keratoses: a non-prescription balm with panthenol, madecassoside, and metal salts vs a topical antibiotic
A Systematic Review of the Effect of Centella asiatica on Wound Healing.
Int J Environ Res Public Health (2022) · Systematic review
PRISMA systematic review identified only four clinical trials meeting inclusion criteria — a small human evidence base
Bimatoprost (lashes) has a higher evidence score (8/10 vs 5/10) and wins in 2 of 3 categories.
No known interactions between Bimatoprost (lashes) and Centella Asiatica (Cica) have been documented in our database. However, always consult a healthcare provider before combining supplements.