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Head-to-head evidence comparison — which supplement is right for you?
CoQ10 vs Vitex: CoQ10 has the stronger overall evidence (8 vs 7/10); they're alternatives for fertility support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
CoQ10 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
9 of 10 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both CoQ10 and Vitex have evidence — compare verdict strength side-by-side.
100-300mg daily
With fatty meal
Ubiquinol (reduced form)
20-40mg extract (standardized to 0.5% agnuside). The cited trials used 20 to 30 mg of extract a day.
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
and 1 more not shown
4-12 weeks
8-12 weeks
4-8 weeks
2-8 weeks
1-3 cycles
2-3 cycles
1-2 cycles
Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
Reproductive sciences (Thousand Oaks, Calif.) (2023) · Meta analysis · n=1021
Meta-analysis of 9 randomised trials with 1,021 women with polycystic ovary syndrome.
Coenzyme Q10 for heart failure
The Cochrane database of systematic reviews (2021) · Meta analysis · n=1573
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
Antioxidants for female subfertility
The Cochrane database of systematic reviews (2017) · Meta analysis · n=6510
This suggests that among subfertile women with an expected clinical pregnancy rate of 22%, the rate among women using antioxidants would be between 27% and 33%.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=520
Out of 21 clinical trials, three double-blind placebo-controlled studies (520 females) met the reporting criteria, testing the characterised extracts Ze 440 and BNO 1095.
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical narrative review of published systematic reviews and meta-analyses of herbal remedies. It pools no data of its own.
The points come from one dose-finding RCT of the Ze 440 extract in 162 women with PMS over three cycles, at 8, 20 or 30 mg a day (PMID 23022391). Total symptom scores improved more at 20 mg than with placebo or 8 mg, and 30 mg did not improve them further than 20 mg, so the curve is flat above 20 mg. All three doses were well tolerated, and no higher dose of this extract was tested. A meta-analysis of 3 trials of characterised extracts (Ze 440, BNO 1095; 520 women) found Vitex users 2.57 times more likely to remit (PMID 31780016). A broader pooled effect was large but rated explorative because of high risk of bias, heterogeneity (I² 91%) and publication bias (PMID 28237870).
AI-estimated from published studies. Interpret as directional guidance.
CoQ10 has a higher evidence score (8/10 vs 7/10) and wins in 3 of 3 categories.
For fertility support, CoQ10 has a higher relevance score (90 vs 35).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.