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Head-to-head evidence comparison — which supplement is right for you?
DHEA vs Glycine: Glycine has the stronger overall evidence (6.5 vs 5.5/10); they're alternatives for support mood — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Glycine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
3 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
1 of 2 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both DHEA and Glycine have evidence — compare verdict strength side-by-side.
25-50mg for women; 50-100mg for men (start low) (the one cited trial used 50 mg a day in women with adrenal insufficiency, no cited trial studied men, and a cited meta-analysis in postmenopausal women with normal adrenal function found no significant benefit)
Morning (mimics natural rhythm)
Micronized DHEA capsules
3g before bed (no cited trial states the dose it used)
30-60 minutes before bed
Powder (dissolves easily, tastes sweet)
4-8 weeks
8-12 weeks
First few nights
Next morning
Immediate
Dehydroepiandrosterone for depressive symptoms: A systematic review and meta-analysis of randomized controlled trials
Journal of neuroscience research (2020) · Meta analysis · n=742
No hormonal changes that indicated any risk to the participants' health were seen.
Hormonal Treatments and Vaginal Moisturizers for Genitourinary Syndrome of Menopause : A Systematic Review
Annals of internal medicine (2024) · Systematic review
Systematic review of 46 RCTs of at least 8 weeks in postmenopausal women with genitourinary syndrome of menopause, too varied to pool.
TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis
Reproductive biology and endocrinology : RB&E (2023) · Meta analysis · n=2323
Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review
GeroScience (2024) · Systematic review
The nervous system demonstrated the most positive effects, including improved psychiatric symptoms from longer-term glycine administration in psychiatric populations.
Glutamatergic drugs for schizophrenia
The Cochrane database of systematic reviews (2006) · Meta analysis · n=358
NMDA receptor co-agonists glycine and D-serine showed some effects in reducing the negative symptoms of schizophrenia (n=132, SMD -0.66, CI -1.0 to -0.3, p=0.0004), but the magnitude of the effect was moderate.
Ingestion of a Whey Plus Collagen Protein Blend Increases Myofibrillar and Muscle Connective Protein Synthesis Rates
Medicine and science in sports and exercise (2025) · Rct · n=28
In addition, myofibrillar protein synthesis rates were higher in BLEND compared with PLA in both the rested (0.038 ± 0.008 and 0.031 ± 0.006%·h -1 , respectively; P < 0.05) and exercised (0.052 ± 0.011 and 0.039 ± 0.009%·h -1 , respectively; P < 0.01) leg.
Glycine has a higher evidence score (6.5/10 vs 5.5/10) and wins in 2 of 3 categories.
For support mood, DHEA has a higher relevance score (85 vs 45).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
Mostly hype unless you’re deficient — what has modest evidence vs what doesn’t, and when to see a doctor.
Ashwagandha, L-theanine, magnesium, saffron — what actually helps stress, and the safety caveats.
When to take what, with or without food, and which supplements compete vs pair well.
Melatonin, magnesium, glycine, L-theanine — tiered by evidence, plus a wind-down timeline.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.