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Head-to-head evidence comparison — which supplement is right for you?
Diosmin vs Red Vine Leaf Extract: Diosmin has the stronger overall evidence (7 vs 5.4/10); they're alternatives for leg circulation & vein health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Diosmin wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Diosmin and Red Vine Leaf Extract have evidence — compare verdict strength side-by-side.
1000mg MPFF daily (900mg diosmin + 100mg hesperidin); acute hemorrhoid protocols use higher short-term doses (a typical label dose, no cited trial states the dose it used)
With meals
MPFF (micronized diosmin + hesperidin)
360 mg standardised red vine leaf extract once daily, up to 720 mg once daily. These are the doses given in the placebo-controlled trials, for 6 to 12 weeks.
Any time of day
Standardised red vine leaf dry extract, 360 to 720 mg
2-8 weeks
2-8 weeks
Days-weeks
6-12 weeks
6-12 weeks
Days
Efficacy of micronized purified flavonoid fraction (Daflon(R)) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Int Angiol (2018) · Meta analysis
MPFF improved leg symptoms, edema, and quality of life in chronic venous disease
Phlebotonics for venous insufficiency.
Cochrane Database Syst Rev (2020) · Meta analysis · n=7690
Cochrane: phlebotonics probably reduce edema (moderate-certainty evidence)
Phlebotonics for haemorrhoids.
Cochrane Database Syst Rev (2012) · Meta analysis
Phlebotonics improved hemorrhoid symptoms (bleeding, itching, discharge)
Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial.
Arzneimittelforschung (2000) · Rct · n=260
Randomised, double-blind, placebo-controlled multicentre trial in 260 outpatients with stage I to incipient stage II chronic venous insufficiency, not using compression stockings: placebo, 360 mg or 720 mg once daily for 12 weeks
Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study.
Eur J Vasc Endovasc Surg (2011) · Rct · n=248
Registered (NCT00855179) randomised, double-blind, placebo-controlled multicentre trial of 720 mg/day for 12 weeks in people with CEAP C3 to C4a chronic venous insufficiency and moderate to severe symptoms. The full-analysis set was 248 (122 placebo, 126 extract)
Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study.
Drugs R D (2004) · Crossover · n=71
Randomised, double-blind, placebo-controlled crossover trial in 71 people with stage I or II chronic venous insufficiency: 360 mg once daily or placebo for 6 weeks, a 4-week washout, then the other treatment
Diosmin has a higher evidence score (7/10 vs 5.4/10) and wins in 2 of 3 categories.
For leg circulation & vein health, Diosmin has a higher relevance score (48 vs 40).
No known interactions between Diosmin and Red Vine Leaf Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.