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Head-to-head evidence comparison — which supplement is right for you?
Fenugreek and PEA are closely matched across evidence, studies, and safety.
Verdict
Likely helps
13 of 14 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
6 of 6 studies with measurable effects showed benefit.
Top outcomes
500-600mg extract (standardized)
With meals
Standardized extract (Testofen, Furosap)
600-1200mg
With meals, Split into 2-3 doses
Micronized or ultra-micronized PEA
4-8 weeks
8-12 weeks
Within days
2-8 weeks
4-8 weeks
Ongoing
Dietary supplements for dysmenorrhoea
The Cochrane database of systematic reviews (2016) · Meta analysis · n=3101
Supplements versus other supplementsThere was no evidence of a difference in effectiveness between ginger and zinc sulphate (MD 0.02 points, 95% CI -0.58 to 0.62; one RCT, 101 women).
The effect of flour-based foods intake in the reduction of cardiometabolic risk: A systematic review
Critical reviews in food science and nutrition (2024) · Systematic review
Chia flour, green banana flour, soy flour, and fenugreek powder showed improvements in blood pressure measurements.
Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-Analysis
Medicina (Kaunas, Lithuania) (2023) · Meta analysis · n=894
The mean difference with 95% confidence intervals (CI) was calculated to represent the analysis.
Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=742
These two obtained scores corresponded to a 35.1% pain intensity reduction within the first month, followed by a further 35.4% during the second month.
Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
Nutrients (2023) · Meta analysis · n=774
PEA was found to reduce pain scores relative to comparators in a pooled estimate, with a standard mean difference of 1.68 (95% CI 1.05 to 2.31, p = 0.00001).
Navigating agitation in neurodevelopmental disorders: A comparative study of pharmacotherapies via network meta-analysis in children and adults with autism spectrum disorder or intellectual disabilities
Journal of psychopharmacology (Oxford, England) (2025) · Meta analysis · n=2503
Importantly, these treatments were generally well-tolerated, with no significant increase in all-cause dropouts compared to placebo, highlighting their suitability for clinical use in managing agitation in individuals with ASD or ID.
Multiple meta-analyses show modest but consistent reductions in fasting blood glucose. Effects appear stronger in diabetic populations. Conservative estimates given heterogeneity in study designs and extract standardization.
Based on multiple meta-analyses showing ~35% pain reduction. Studies primarily used micronized formulations which may have better bioavailability than standard forms. Most benefits observed within 4-6 weeks of treatment.
AI-estimated from published studies. Interpret as directional guidance.
Both Fenugreek and PEA are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, PEA has a higher relevance score (85 vs 70).
No known interactions between Fenugreek and PEA have been documented in our database. However, always consult a healthcare provider before combining supplements.