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Head-to-head evidence comparison — which supplement is right for you?
Green Tea Extract vs Vitex: Green Tea Extract has the stronger overall evidence (7.5 vs 7/10); they're alternatives for cycle & hormonal symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Green Tea Extract wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
5 of 7 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Green Tea Extract and Vitex have evidence — compare verdict strength side-by-side.
250-338mg EGCG a day with food (about 500-675mg of an extract standardised to 50% EGCG). 338 mg is a review-derived precaution (PMID 29580974), not an upper limit and not proof of safety
With meals, Morning or pre-exercise
Standardized extract (45-50% EGCG)
20-40mg extract (standardized to 0.5% agnuside). The cited trials used 20 to 30 mg of extract a day.
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
and 2 more not shown
and 1 more not shown
Acute and 4-8 weeks
Acute
30-60 minutes
1-3 cycles
2-3 cycles
1-2 cycles
Green tea (Camellia sinensis) for the prevention of cancer
The Cochrane database of systematic reviews (2020) · Meta analysis · n=1795
For incident prostate cancer, the summary risk ratio (RR) in the green tea-supplemented participants was 0.50 (95% confidence interval (CI) 0.18 to 1.36), based on three studies and involving 201 participants (low-certainty evidence).
Impact of flavan-3-ols on blood pressure and endothelial function in diverse populations: a systematic review and meta-analysis of randomized controlled trials
European journal of preventive cardiology (2025) · Meta analysis · n=5205
Flavan-3-ol interventions included epicatechin, epigallocatechin-gallate, cocoa products, tea, grape extract, and apples delivering 586 mg (95% CI 510, 662) total flavan-3-ols.
The effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials
The British journal of nutrition (2024) · Meta analysis · n=3802
Pooled effect sizes indicated that BM, BFP, BMI and MDA significantly reduced following GTE supplementation.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=520
Out of 21 clinical trials, three double-blind placebo-controlled studies (520 females) met the reporting criteria, testing the characterised extracts Ze 440 and BNO 1095.
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical narrative review of published systematic reviews and meta-analyses of herbal remedies. It pools no data of its own.
Both points come from a systematic review of 17 randomised trials in 1,356 healthy adults (PMID 27324590), which found that 107 to 856 mg of EGCG a day for 4 to 14 weeks lowered LDL cholesterol by about 9.3 mg/dl, at any dose in that range. The effect depended slightly on baseline lipids, not on dose, so the curve is flat. A 12-week trial at 856.8 mg a day in 102 women with central obesity saw a non-significant downward trend in LDL (PMID 26093535). No optimum was identified, and the 856 mg point is not a safety ceiling: a safety review derived 338 mg EGCG a day as the safe intake for solid supplement doses (PMID 29580974).
The points come from one dose-finding RCT of the Ze 440 extract in 162 women with PMS over three cycles, at 8, 20 or 30 mg a day (PMID 23022391). Total symptom scores improved more at 20 mg than with placebo or 8 mg, and 30 mg did not improve them further than 20 mg, so the curve is flat above 20 mg. All three doses were well tolerated, and no higher dose of this extract was tested. A meta-analysis of 3 trials of characterised extracts (Ze 440, BNO 1095; 520 women) found Vitex users 2.57 times more likely to remit (PMID 31780016). A broader pooled effect was large but rated explorative because of high risk of bias, heterogeneity (I² 91%) and publication bias (PMID 28237870).
AI-estimated from published studies. Interpret as directional guidance.
Green Tea Extract has a higher evidence score (7.5/10 vs 7/10) and wins in 2 of 3 categories.
For cycle & hormonal symptoms, Vitex has a higher relevance score (85 vs 20).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.