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Head-to-head evidence comparison — which supplement is right for you?
Iodine vs Red Vine Leaf Extract: Iodine has the stronger overall evidence (8.5 vs 5.4/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Iodine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Limited support
1 of 4 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
150-300mcg for maintenance; higher only if deficient under supervision
Any time with food
Potassium iodide (most common and studied)
360 mg standardised red vine leaf extract once daily, up to 720 mg once daily. These are the doses given in the placebo-controlled trials, for 6 to 12 weeks.
Any time of day
Standardised red vine leaf dry extract, 360 to 720 mg
and 2 more not shown
4-12 weeks
4-8 weeks
6-12 weeks
6-12 weeks
Days
Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis
Nutrients (2023) · Meta analysis · n=42269
Birth weight was similar between UIC ≥ 150 μg/L and <150 μg/L (difference = 30 g, 95% CI −22 to 83, p = 0.3, n = 13, I2 = 89%) with no evidence of linear trend (4 g per 50 μg/L, −3 to 10, p = 0.2, n = 12, I2 = 80%).
Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders
The Cochrane database of systematic reviews (2019) · Meta analysis · n=4317
This is equivalent to an increase of 38.32 µg/L (95% CI 24.03 to 52.61 µg/L).
Systematic review and meta-analysis of iodine nutrition in modern vegan and vegetarian diets
The British journal of nutrition (2023) · Meta analysis · n=4421
Vegan diets had the poorest iodine intake (17·3 µg/d) and were strongly associated with lower iodine intake (P = < 0·001) compared with omnivorous diets.
Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial.
Arzneimittelforschung (2000) · Rct · n=260
Randomised, double-blind, placebo-controlled multicentre trial in 260 outpatients with stage I to incipient stage II chronic venous insufficiency, not using compression stockings: placebo, 360 mg or 720 mg once daily for 12 weeks
Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study.
Eur J Vasc Endovasc Surg (2011) · Rct · n=248
Registered (NCT00855179) randomised, double-blind, placebo-controlled multicentre trial of 720 mg/day for 12 weeks in people with CEAP C3 to C4a chronic venous insufficiency and moderate to severe symptoms. The full-analysis set was 248 (122 placebo, 126 extract)
Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study.
Drugs R D (2004) · Crossover · n=71
Randomised, double-blind, placebo-controlled crossover trial in 71 people with stage I or II chronic venous insufficiency: 360 mg once daily or placebo for 6 weeks, a 4-week washout, then the other treatment
Iodine has a higher evidence score (8.5/10 vs 5.4/10) and wins in 2 of 3 categories.
No known interactions between Iodine and Red Vine Leaf Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
Selenium helps; iodine can WORSEN Hashimoto’s. The honest take on "thyroid support".
What’s safe while nursing, the truth about milk-supply herbs, and what to avoid (it passes into milk).
Commonly recommended vs ask-your-clinician vs avoid — a general, safety-first overview.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.