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Head-to-head evidence comparison — which supplement is right for you?
Omega-3 vs Red Vine Leaf Extract: Omega-3 has the stronger overall evidence (9 vs 5.4/10); they're alternatives for support heart health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Omega-3 wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
10 of 15 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Omega-3 and Red Vine Leaf Extract have evidence — compare verdict strength side-by-side.
2-3g combined EPA+DHA daily (a typical label dose, not the dose used in the cited trials, which gave 1 g or 3.25 g of omega-3 a day, or 1 to 4 g of fish oil a day without stating its EPA+DHA content)
With meals containing fat
Triglyceride form fish oil
360 mg standardised red vine leaf extract once daily, up to 720 mg once daily. These are the doses given in the placebo-controlled trials, for 6 to 12 weeks.
Any time of day
Standardised red vine leaf dry extract, 360 to 720 mg
4-8 weeks
2-4 weeks
Immediate
4-12 weeks
6-12 weeks
6-12 weeks
Days
Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
The New England journal of medicine (2019) · Rct · n=25871
During a median follow-up of 5.3 years, a major cardiovascular event occurred in 386 participants in the n-3 group and in 419 in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.80 to 1.06; P=0.24).
Omega-3 fatty acids for intermittent claudication
The Cochrane database of systematic reviews (2024) · Meta analysis · n=1830
Omega-3 compared with a control may have little to no effect on ankle-brachial index (MD -0.02, 95% CI -0.08 to 0.04; 3 studies, 168 participants; very low-certainty evidence).
A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)
Nutritional neuroscience (2024) · Meta analysis · n=587
12 RCTs with 587 subjects: omega-3 supplementation increased serum BDNF versus placebo (SMD 0.72, 95% CI 0.28 to 1.15), with high heterogeneity (I2 = 84.39%).
Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial.
Arzneimittelforschung (2000) · Rct · n=260
Randomised, double-blind, placebo-controlled multicentre trial in 260 outpatients with stage I to incipient stage II chronic venous insufficiency, not using compression stockings: placebo, 360 mg or 720 mg once daily for 12 weeks
Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study.
Eur J Vasc Endovasc Surg (2011) · Rct · n=248
Registered (NCT00855179) randomised, double-blind, placebo-controlled multicentre trial of 720 mg/day for 12 weeks in people with CEAP C3 to C4a chronic venous insufficiency and moderate to severe symptoms. The full-analysis set was 248 (122 placebo, 126 extract)
Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study.
Drugs R D (2004) · Crossover · n=71
Randomised, double-blind, placebo-controlled crossover trial in 71 people with stage I or II chronic venous insufficiency: 360 mg once daily or placebo for 6 weeks, a 4-week washout, then the other treatment
The points are the dose bands of a meta-analysis of 10 randomised trials with 1,426 adults (PMID 37028202): EPA-rich products at 1 to under 2 g of EPA a day reduced depression severity (SMD -0.43), while 2 g a day or more did not (SMD -0.20, not significant), so the 2 g point is plotted as no effect. Doses are grams of EPA, not EPA plus DHA. The Cochrane review of 33 placebo-controlled trials found a small to modest effect, unlikely to be clinically meaningful and rated very low certainty, with no difference in remission or response (PMID 34817851). No trial compared doses directly.
AI-estimated from published studies. Interpret as directional guidance.
Omega-3 has a higher evidence score (9/10 vs 5.4/10) and wins in 2 of 3 categories.
For support heart health, Omega-3 has a higher relevance score (82 vs 40).
No known interactions between Omega-3 and Red Vine Leaf Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.