Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Pelargonium Sidoides vs Vitamin D3: Vitamin D3 has the stronger overall evidence (7.5 vs 6.5/10); they're alternatives for support immune system — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Vitamin D3 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Probably helps
7 of 14 studies with measurable effects showed benefit.
Top outcomes
Liquid EPs 7630: 30 drops three times daily for adults during an acute infection (the cited trials used this dose in 12 to 18 year olds, and gave adults 30, 60 or 90 mg of EPs 7630 a day as tablets)
Spread through the day
Liquid extract (EPs 7630)
2000-4000 IU daily
Morning with breakfast
D3 (cholecalciferol) softgel or liquid
and 1 more not shown
Days 4-7 of an acute episode
Within the acute illness window
During use
4-8 weeks
4-8 weeks
2-4 weeks
4-8 weeks
Pelargonium sidoides extract for treating acute respiratory tract infections.
Cochrane Database Syst Rev (2013) · Systematic review · n=10 trials; ~746 adults and ~819 children
Liquid EPs 7630 showed effectiveness for acute bronchitis in both adults and children; tablets did not
Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents.
Pediatr Int (2012) · Rct · n=220 children/adolescents
Significantly greater BSS reduction with EPs 7630 versus placebo (P<0.0001)
Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides.
Wien Med Wochenschr (2010) · Rct · n=406 adults
All three active dose groups improved patient-reported outcomes versus placebo at day 7
Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial
Nature communications (2025) · Rct · n=22220
Ancillary analysis of VITAL: 22,220 adults without T2D randomized to vitamin D3 2000 IU/day or placebo, with a meta-analysis of 3 additional trials.
Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials
Nutrients (2024) · Meta analysis · n=687
TSA revealed that the current RCTs provide sufficient information.
Vitamin D and respiratory tract infections
BMJ (2017) · Meta analysis · n=11321
25 RCTs, 11 321 participants aged 0 to 95 years. Vitamin D reduced acute respiratory tract infection overall (adjusted OR 0.88, 95% CI 0.81 to 0.96).
Both points come from a meta-analysis of double-blind cholecalciferol trials in people aged 60 and over (PMID 15886381). Trials at 700 to 800 IU a day cut hip fracture risk by 26% (RR 0.74) and non-vertebral fractures by 23%, plotted at 800 IU. Trials at 400 IU a day showed no benefit (hip fracture RR 1.15), and the WHI trial of 400 IU with 1,000 mg calcium did not significantly reduce hip fracture (PMID 16481635). Most of these trials also gave calcium, and the Cochrane review found vitamin D alone unlikely to prevent fractures while vitamin D with calcium gave a small reduction (PMID 24729336). Doses above 800 IU were not compared, so no optimal dose or ceiling is set.
AI-estimated from published studies. Interpret as directional guidance.
Vitamin D3 has a higher evidence score (7.5/10 vs 6.5/10) and wins in 3 of 3 categories.
For support immune system, Vitamin D3 has a higher relevance score (92 vs 62).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The honest tier list — proven staples vs situational vs mostly marketing. The hub the other guides feed into.
On Ozempic/Wegovy/Mounjaro? What actually helps — muscle preservation, GI relief, nutrient gaps (no upsell).
Tired? Why most "energy" pills only work if they fix a deficit — and how to find yours first.
Berberine, inositol, magnesium vs the cinnamon/chromium hype — and the med-interaction warning.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.