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Head-to-head evidence comparison — which supplement is right for you?
Vitamin B6 and Vitex are closely matched across evidence, studies, and safety.
Verdict
Likely helps
12 of 16 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Vitamin B6 and Vitex have evidence — compare verdict strength side-by-side.
25-100mg daily
Morning with food, Can take with other B vitamins
P-5-P (Pyridoxal-5-Phosphate)
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
2-4 weeks
1-2 cycles
Months of high doses
1-3 cycles
2-3 cycles
1-2 cycles
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
The Cochrane database of systematic reviews (2018) · Meta analysis · n=83000
We found that giving B vitamin supplements to cognitively healthy adults, mainly in their 60s and 70s, probably has little or no effect on global cognitive function at any time point up to 5 years (SMD values from -0.03 to 0.06) and may also have no effect at 5-10 years (SMD -0.01).
Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis
JAMA network open (2024) · Meta analysis · n=492
No association between effect sizes and psychotic severity was found.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Based on systematic review of nutritional interventions for PMS psychological symptoms. Evidence quality limited by study heterogeneity and need for more consistent protocols.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
Both Vitamin B6 and Vitex are closely matched — the best choice depends on your specific health goals.
For testosterone & cortisol balance, Vitex has a higher relevance score (92 vs 52).
No known interactions between Vitamin B6 and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.