SAMe and Trazodone: Can You Take Them Together?

Use caution — significant interaction

SAMe and Trazodone can interact. Risk of serotonin syndrome. Do not combine without prescriber supervision.

What the evidence says

majorconflict· limited evidence

Risk of serotonin syndrome.

SAM-e has antidepressant and serotonergic activity; combined with trazodone the serotonergic effects are additive.

What to do: Do not combine without prescriber supervision.

SAMe

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Trazodone

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Related interactions

5-HTP & Trazodone St. John's Wort & Trazodone Trazodone & Tryptophan

Frequently asked questions

Can you take SAMe and Trazodone together?: SAMe and Trazodone can interact. Risk of serotonin syndrome. Do not combine without prescriber supervision.
Do SAMe and Trazodone interact?: Risk of serotonin syndrome. SAM-e has antidepressant and serotonergic activity; combined with trazodone the serotonergic effects are additive.
Should you separate SAMe and Trazodone?: Do not combine without prescriber supervision.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.