Trazodone and Tryptophan: Can You Take Them Together?

Use caution — significant interaction

Trazodone and Tryptophan can interact. Risk of serotonin syndrome. Do not combine without prescriber supervision.

What the evidence says

majorconflict· limited evidence

Risk of serotonin syndrome.

Tryptophan is the upstream precursor of serotonin; trazodone inhibits serotonin reuptake. The combination increases serotonergic signalling from both ends of the pathway.

What to do: Do not combine without prescriber supervision.

Trazodone

Evidence, dosage & safety →

Tryptophan

Evidence, dosage & safety →

Compare Trazodone vs Tryptophan Check your full stack

Related interactions

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Frequently asked questions

Can you take Trazodone and Tryptophan together?: Trazodone and Tryptophan can interact. Risk of serotonin syndrome. Do not combine without prescriber supervision.
Do Trazodone and Tryptophan interact?: Risk of serotonin syndrome. Tryptophan is the upstream precursor of serotonin; trazodone inhibits serotonin reuptake. The combination increases serotonergic signalling from both ends of the pathway.
Should you separate Trazodone and Tryptophan?: Do not combine without prescriber supervision.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.