St. John's Wort and Trazodone: Can You Take Them Together?

Use caution — significant interaction

St. John's Wort and Trazodone can interact. Risk of serotonin syndrome, plus unpredictable trazodone levels from enzyme induction. Avoid the combination. This is one of the clearest supplement-drug conflicts in the corpus — raise it with your prescriber before starting either.

What the evidence says

majorconflict· moderate evidence

Risk of serotonin syndrome, plus unpredictable trazodone levels from enzyme induction.

St John's wort has serotonergic activity and additionally induces CYP3A4, which metabolises trazodone — so the pair both raises serotonergic load and alters trazodone exposure.

What to do: Avoid the combination. This is one of the clearest supplement-drug conflicts in the corpus — raise it with your prescriber before starting either.

St. John's Wort

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Trazodone

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Compare St. John's Wort vs Trazodone Check your full stack

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Frequently asked questions

Can you take St. John's Wort and Trazodone together?: St. John's Wort and Trazodone can interact. Risk of serotonin syndrome, plus unpredictable trazodone levels from enzyme induction. Avoid the combination. This is one of the clearest supplement-drug conflicts in the corpus — raise it with your prescriber before starting either.
Do St. John's Wort and Trazodone interact?: Risk of serotonin syndrome, plus unpredictable trazodone levels from enzyme induction. St John's wort has serotonergic activity and additionally induces CYP3A4, which metabolises trazodone — so the pair both raises serotonergic load and alters trazodone exposure.
Should you separate St. John's Wort and Trazodone?: Avoid the combination. This is one of the clearest supplement-drug conflicts in the corpus — raise it with your prescriber before starting either.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.

What the evidence says

majorconflict· moderate evidence

Risk of serotonin syndrome, plus unpredictable trazodone levels from enzyme induction.

St John's wort has serotonergic activity and additionally induces CYP3A4, which metabolises trazodone — so the pair both raises serotonergic load and alters trazodone exposure.

What to do: Avoid the combination. This is one of the clearest supplement-drug conflicts in the corpus — raise it with your prescriber before starting either.

Frequently asked questions

Can you take St. John's Wort and Trazodone together?

Do St. John's Wort and Trazodone interact?

Risk of serotonin syndrome, plus unpredictable trazodone levels from enzyme induction. St John's wort has serotonergic activity and additionally induces CYP3A4, which metabolises trazodone — so the pair both raises serotonergic load and alters trazodone exposure.

Should you separate St. John's Wort and Trazodone?

Avoid the combination. This is one of the clearest supplement-drug conflicts in the corpus — raise it with your prescriber before starting either.