St. John's Wort and Tryptophan: Can You Take Them Together?

Use caution — significant interaction

St. John's Wort and Tryptophan can interact. Risk of serotonin syndrome: agitation, tremor, hyperthermia, tachycardia Do not combine without medical supervision

What the evidence says

majorconflict· moderate evidence

Risk of serotonin syndrome: agitation, tremor, hyperthermia, tachycardia

Additive serotonergic activity — a serotonin precursor combined with reuptake inhibition

What to do: Do not combine without medical supervision

St. John's Wort

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Tryptophan

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Related interactions

St. John's Wort & Trazodone 5-HTP & St. John's Wort St. John's Wort & Vitamin D3 Trazodone & Tryptophan

Frequently asked questions

Can you take St. John's Wort and Tryptophan together?: St. John's Wort and Tryptophan can interact. Risk of serotonin syndrome: agitation, tremor, hyperthermia, tachycardia Do not combine without medical supervision
Do St. John's Wort and Tryptophan interact?: Risk of serotonin syndrome: agitation, tremor, hyperthermia, tachycardia Additive serotonergic activity — a serotonin precursor combined with reuptake inhibition
Should you separate St. John's Wort and Tryptophan?: Do not combine without medical supervision

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.