Vitamin D3 and Vitamin E: Can You Take Them Together?

At most a minor interaction

Vitamin D3 and Vitamin E have at most a minor documented interaction. No change needed. Take either with a meal that contains fat.

What the evidence says

minortiming· limited evidence

No established clinically beneficial or harmful interaction.

Both are fat-soluble and are absorbed better with a meal that contains fat. In laboratory models (mouse intestine and Caco-2 cells) the fat-soluble vitamins competed for uptake, and vitamin A reduced uptake of the others. Neither observation shows a clinical effect of taking the two together.

What to do: No change needed. Take either with a meal that contains fat.

Vitamin D3

Evidence, dosage & safety →

Vitamin E

Evidence, dosage & safety →

Compare Vitamin D3 vs Vitamin E Check your full stack

Related interactions

Calcium & Vitamin D3 Vitamin D3 & Vitamin K2 Magnesium & Vitamin D3 Orlistat & Vitamin D3 St. John's Wort & Vitamin D3 Vitamin A & Vitamin D3

Frequently asked questions

Can you take Vitamin D3 and Vitamin E together?: Vitamin D3 and Vitamin E have at most a minor documented interaction. No change needed. Take either with a meal that contains fat.
Do Vitamin D3 and Vitamin E interact?: No established clinically beneficial or harmful interaction. Both are fat-soluble and are absorbed better with a meal that contains fat. In laboratory models (mouse intestine and Caco-2 cells) the fat-soluble vitamins competed for uptake, and vitamin A reduced uptake of the others. Neither observation shows a clinical effect of taking the two together.
Should you separate Vitamin D3 and Vitamin E?: No change needed. Take either with a meal that contains fat.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.