Bryan Johnson — Blueprint (core compounds)

The most-publicized longevity protocol — a 100+ item daily regimen; this documents ~20 of its most-notable compounds from the official protocol page. Documented, not endorsed.

Bryan Johnson is an American entrepreneur, venture capitalist, writer and author . He is the founder and former CEO of Kernel, a company creating devices that monitor and record brain activity, and OS Fund, a venture capital firm that invests in early-stage science and technology companies.

Website ↗Wikipedia ↗

Photo: via Wikimedia Commons

Documented, not endorsed. What Bryan Johnson reports taking (as of 2026-01) — not medical advice, not a recommendation. We sell nothing; each item links to its independently evidence-graded card.

At a glance

Aimed at (inferred from 19 mapped members)

🧬 Longevity & healthspan 13💪 Performance & recovery 8🧠 Cognition 3😌 Mood & stress 3🩺 General health 3⚖️ Metabolic & weight 2

Evidence makeup

4 Strong 9 Moderate 4 Emerging 2 Gated / research compound

2 of 19 mapped items are gated research compounds — informational only.

The stack · 20 compounds

Core

⏳ NMN
NAD+ precursor.
Moderate 5.5500 mg (alternated with NR)
🔬 Nicotinamide Riboside
NAD+ precursor.
Moderate 5.5450 mg (alternated with NMN)
🧬 Metforminresearch compound
Glucose/metabolic + longevity (he calls it experimental).
Emerging 4.0500 mg, cycled 6 wks on/off
⚗️ Lithium Orotate
Low-dose lithium as a brain nutrient (renewed emphasis after 2025 Alzheimer’s research).
Emerging 2.21 mg elemental
⚡ CoQ10
Mitochondrial/cardiovascular.
Strong 8.050 mg (ubiquinol)
🐟 Omega-3
Heart/brain.
Strong 9.0800 mg EPA/DHA (algae) · breakfast
☀️ Vitamin D3
Baseline micronutrient.
Moderate 7.52000 IU
⚡ Creatine
Muscle/cognitive.
Strong 9.5~7.5 g
⚗️ Calcium AKG
Geroprotective signal (mouse data).
Emerging 3.5~2 g (Ca-AKG)

Situational

💫 Taurine
Longevity/metabolic.
Moderate 7.51500 mg
🦵 Glucosamine
Joint health (also a longevity signal).
Moderate 5.5750 mg
🧀 Spermidine
Autophagy.
Emerging 4.210 mg
🍅 Lycopene
Antioxidant.
Emerging 4.515 mg
🦐 Astaxanthin
Antioxidant.
Moderate 5.012 mg
💧 Hyaluronic Acid
Skin/joint.
Moderate 5.5120 mg
🛡️ Zinc
Baseline micronutrient.
Strong 8.515 mg
🌿 Ashwagandha
Stress/adaptogen.
Moderate 7.5no dose info
✨ Collagen
Skin/connective tissue.
Moderate 6.0~12 g · breakfast
🧪 NDGA (Nordihydroguaiaretic acid)research compound
Mouse-lifespan ITP signal; thin human evidence.
Emerging 3.050 mg (per his announcement; not on the official panel)
Extra-virgin olive oilnot yet mapped
Heart/brain/metabolism (no SupStack card yet).
~30 mL · breakfast

Not yet mapped: Extra-virgin olive oil.

“no dose info” = publicly known to take it, but no reliable dose has been stated.

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“Start” adds the 17 evidence-graded compounds to your own stack to edit — gated research compounds excluded. Not an endorsement.

Synergies (1)

CoQ10 + Omega-3 — Taking CoQ10 with fats increases absorption by 3-5x

Documented supplement–supplement interactions between members of this stack — not a personal interaction check. Full interaction checker →

Compare with another stack

All comparisons →

Sources: Official Blueprint protocol (01.23.2026) · “I stopped taking rapamycin”