David Sinclair — NAD+ / sirtuin longevity regimen

The Harvard geneticist’s widely-cited NAD+/sirtuin-centric regimen — NMN, resveratrol and a metabolic agent — reconstructed from his book, podcast and interviews. He resists the "fixed protocol" framing; documented as reported, not endorsed.

David Andrew Sinclair is an Australian-American biologist and academic known for his research on aging and epigenetics . Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F.

Website ↗Wikipedia ↗

Photo: Editor5627 / CC BY-SA 4.0, via Wikimedia Commons

Documented, not endorsed. What David Sinclair, PhD reports taking (as of 2026-06) — not medical advice, not a recommendation. We sell nothing; each item links to its independently evidence-graded card.

At a glance

Aimed at (inferred from 11 mapped members)

🧬 Longevity & healthspan 10🫀 Cardiovascular 2

Evidence makeup

6 Moderate 3 Emerging 2 Gated / research compound

2 of 11 mapped items are gated research compounds — informational only.

The stack · 11 compounds

Core

⏳ NMN
NAD+ precursor — sirtuin fuel.
Moderate 5.5~1 g · morning
🍷 Resveratrol
Sirtuin activator; taken with fat for absorption.
Emerging 4.5~1 g · morning, in yogurt
🌿 Berberine
AMPK activator — switched to from metformin (2025) for GI tolerance.
Moderate 7.5~1 g · morning
☀️ Vitamin D3
Immune/general; guided by blood levels.
Moderate 7.5no dose info
🦴 Vitamin K2
Pairs with D3 for calcium handling.
Moderate 6.0no dose info
🩸 Rosuvastatin (Crestor)research compound
Prescription statin since his 20s — family cardiovascular history.
Emerging 4.5no dose info

Situational

🧀 Spermidine
Autophagy.
Emerging 4.2no dose info
🍓 Fisetin
Senolytic — taken intermittently, not daily.
Emerging 3.5~500 mg, pulsed
💪 TMG
Methyl donor to offset the methylation demand of high-dose NMN.
Moderate 5.8no dose info
⚡ Alpha Lipoic Acid
Antioxidant (older mention; may be intermittent).
Moderate 7.0no dose info
💊 Aspirin (low-dose)research compound
Low-dose; de-emphasized as the aspirin evidence shifted.
Emerging 3.0~81 mg

“no dose info” = publicly known to take it, but no reliable dose has been stated.

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“Start” adds the 9 evidence-graded compounds to your own stack to edit — gated research compounds excluded. Not an endorsement.

Synergies (1)

Vitamin D3 + Vitamin K2 — K2 prevents arterial calcification while enhancing bone mineralization from vitamin D

Documented supplement–supplement interactions between members of this stack — not a personal interaction check. Full interaction checker →

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Sources: Lifespan (2019) & Lifespan podcast · 2025 Diamandis interview (metformin→berberine switch)