Peter Attia — longevity & ApoB-lowering regimen

A physician-led healthspan regimen built around aggressive ApoB/lipid lowering, cyclical rapamycin, high-dose omega-3, and a sleep/recovery layer — reconstructed from his public statements. Documented for reference, not endorsed.

Peter Attia is a Canadian-American author and former researcher known for his work in longevity medicine . He is the author of Outlive: The Science and Art of Longevity.

Website ↗Wikipedia ↗

Photo: Jop van Velthuis / CC BY-SA 4.0, via Wikimedia Commons

Documented, not endorsed. What Peter Attia, MD reports taking (as of 2026-06) — not medical advice, not a recommendation. We sell nothing; each item links to its independently evidence-graded card.

At a glance

Aimed at (inferred from 17 mapped members)

🧬 Longevity & healthspan 9😌 Mood & stress 8🫀 Cardiovascular 5⚖️ Metabolic & weight 4🌙 Sleep 3💪 Performance & recovery 3

Evidence makeup

3 Strong 7 Moderate 1 Emerging 6 Gated / research compound

6 of 17 mapped items are gated research compounds — informational only.

The stack · 17 compounds

Core

🩸 Rosuvastatin (Crestor)research compound
Primary statin for ApoB lowering.
Emerging 4.5no dose info
🩸 Ezetimibe (Zetia)research compound
Cholesterol-absorption inhibitor, added to a statin for further ApoB reduction.
Emerging 4.4no dose info
💊 Aspirin (low-dose)research compound
Low-dose antiplatelet, used selectively for cardiovascular risk.
Emerging 3.081 mg (baby aspirin) · daily
🐟 Omega-3
High-dose EPA/DHA for lipid and cardiovascular support.
Strong 9.0~2–4 g EPA/DHA · with meals
⏳ Rapamycinresearch compound
mTOR inhibition as a geroprotector — explicitly experimental.
Emerging 4.5cyclical, low-dose · weekly-ish, off-label
☀️ Vitamin D3
Repletion to a target blood level.
Moderate 7.5to target serum 25-OH-D
✨ Magnesium
General magnesium repletion (multiple salts).
Strong 8.5split forms
🧬 Methylfolate
Methylated folate (he has discussed an MTHFR variant).
Moderate 6.0no dose info
🔴 Vitamin B12
B12 alongside methylfolate.
Moderate 7.5no dose info
⚡ Creatine
Muscle, performance, and cognitive support.
Strong 9.5~5 g · daily

Situational

🫀 Bempedoic Acidresearch compound
Additional non-statin LDL lowering when targets are unmet.
Emerging 4.3no dose info
🩸 Evolocumab (Repatha)research compound
PCSK9 inhibitor for the most aggressive ApoB targets.
Emerging 4.5no dose info
⚡ B-Complex
Broader B-vitamin coverage.
Moderate 6.5no dose info
🌿 Curcumin
Anti-inflammatory; he has cited a high-absorption form.
Moderate 7.5Theracurmin form
🧠 Magnesium L-Threonate
Part of his sleep stack.
Emerging 4.8evening · before bed
🌿 Ashwagandha
Sleep / stress component.
Moderate 7.5evening · before bed
💤 Glycine
Sleep-onset support.
Moderate 6.5evening · before bed

“no dose info” = publicly known to take it, but no reliable dose has been stated.

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“Start” adds the 11 evidence-graded compounds to your own stack to edit — gated research compounds excluded. Not an endorsement.

Watch-outs (1)

Magnesium L-Threonate ✕ Magnesium — Combined elemental magnesium may exceed the tolerable upper intake, causing diarrhea/GI upset Count total elemental magnesium across both; keep supplemental magnesium near the ~350mg UL

Synergies (4)

Omega-3 + Curcumin — Synergistic anti-inflammatory effects through complementary mechanisms
Vitamin D3 + Magnesium — Magnesium deficiency impairs vitamin D metabolism and effectiveness
Magnesium + Glycine — Enhanced sleep quality and relaxation
Vitamin B12 + Methylfolate — Work together in one-carbon metabolism; deficiency of either impairs both pathways

Documented supplement–supplement interactions between members of this stack — not a personal interaction check. Full interaction checker →

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Sources: Outlive (2023) & The Drive podcast AMAs