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Evidence-based supplements similar to Sage, ranked by shared goals and clinical evidence. Compare any of them head-to-head below.
Acetylcholinesterase inhibitor from club moss, studied mainly for Alzheimer's and dementia; cognitive evidence is mixed and limited by trial quality.
Standardized leaf extract with modest meta-analytic benefit in dementia and mild cognitive impairment — but no measurable cognitive benefit in healthy adults and no effect on preventing dementia.
Nutritional insurance that fills micronutrient gaps. In the large COSMOS trial, a daily multivitamin improved memory and slowed cognitive decline in older adults — but it did not reduce total cancer, cardiovascular disease, or mortality.
Enhances memory formation and recall by supporting synaptic communication — benefits build over 8-12 weeks of consistent use.
Key brain membrane phospholipid that facilitates neurotransmitter release, memory formation, and post-exercise cortisol reduction.
A vitamin B3 precursor that reliably raises cellular NAD+ levels and is well tolerated — but human trials have so far shown mostly null or mixed results on the functional outcomes (muscle, metabolism, blood pressure, cognition) that elevation is meant to drive.
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.