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Head-to-head evidence comparison — which supplement is right for you?
Phosphatidylserine vs Sage: Phosphatidylserine has the stronger overall evidence (6 vs 6/10); they're alternatives for improve memory & learning — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Phosphatidylserine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
1 of 1 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Phosphatidylserine and Sage have evidence — compare verdict strength side-by-side.
100-300mg daily
With meals, Evening or post-workout for cortisol
Soy or sunflower-derived phosphatidylserine
300–600 mg standardized extract daily
With breakfast, With dinner (split dosing)
Standardized extract (300–600 mg, 2.5% rosmarinic acid)
and 4 more not shown
4-12 weeks
2 weeks
4-8 weeks
4–8 weeks
4–8 weeks
4–8 weeks
8–12 weeks
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
Journal of affective disorders (2025) · Rct · n=190
The capsule combined phosphatidylserine (63 mg/day) with α-linolenic acid, ginkgo flavonoids, vitamins B1 and B6 and folic acid, taken for 12 months. The effect cannot be credited to phosphatidylserine alone.
Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
Dementia and geriatric cognitive disorders (2010) · Rct · n=157
157 participants were randomized to receive either PS-DHA or placebo for 15 weeks.
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
Journal of alternative and complementary medicine (2021) · Meta analysis · n=216
Four studies met the inclusion criteria for the narrative review (n = 344) and three for the meta-analysis (n = 216).
Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease.
CNS Neuroscience & Therapeutics (2014) · Systematic review
Eight clinical studies were included: six on cognitive performance in healthy subjects and two on Alzheimer's disease.
Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.
BMC Complementary Medicine and Therapies (2025) · Rct · n=70
70 women with newly diagnosed PCOS were randomized to receive either 330 mg of S. officinalis extract or placebo daily for eight weeks.
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
J Clin Pharm Ther (2003) · Rct · n=42
42 patients aged 65-80 with mild to moderate Alzheimer's disease were randomized to a fixed dose of S. officinalis extract (60 drops/day) or placebo for 4 months.
The dose points come from one randomised, double-blind trial of 78 Japanese adults aged 50 to 69 with memory complaints (PMID 21103034), who took 100 mg or 300 mg a day of soy-derived phosphatidylserine or placebo for 6 months. Test scores rose similarly in all groups, placebo included, so neither dose is shown to beat placebo. Memory scores rose from baseline on both doses only in people with low baseline scores, a within-group result. No side effects and no change in blood markers were seen, which is why the ceiling is 300 mg. The PS-DHA memory trial (PMID 20523044, 157 older adults) states no dose, the 190-person trial in mild cognitive impairment (PMID 39317299) gave 63 mg inside a multi-ingredient capsule, and the pooled 200 to 300 mg effect on inattention (PMID 33539192) is in children with ADHD, so none of them can sit on this curve.
Based on multiple RCTs showing improvements in word recall, working memory, and attention. Effects varied by specific cognitive domain and population. Most studies used standardized extracts.
AI-estimated from published studies. Interpret as directional guidance.
Phosphatidylserine has a higher evidence score (6/10 vs 6/10) and wins in 2 of 3 categories.
For improve memory & learning, Phosphatidylserine has a higher relevance score (80 vs 78).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.