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Head-to-head evidence comparison — which supplement is right for you?
5-HTP wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
6 of 7 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both 5-HTP and Passionflower have evidence — compare verdict strength side-by-side.
50-100mg for sleep; 150-300mg for mood
For sleep: 30-45 minutes before bed, For mood: 2-3 divided doses with meals
Capsules
250-500mg extract (or 2g dried herb)
For anxiety: as needed, For sleep: 30-60 minutes before bed
Standardized extract capsules
2-4 weeks
1-2 weeks
2-4 weeks
First 1-2 weeks
30 min - 2 hours
30-60 minutes
30-60 minutes
Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD)
The Cochrane database of systematic reviews (2022) · Systematic review · n=2023
This review provides uncertain evidence only regarding the use of hydrocortisone, propranolol, dexamethasone, omega-3 fatty acids, gabapentin, paroxetine, PulmoCare formula, Oxepa formula, or 5-hydroxytryptophan as universal PTSD prevention strategies.
Combination pharmacotherapy for the treatment of fibromyalgia in adults
The Cochrane database of systematic reviews (2018) · Systematic review · n=1474
Two studies only reported any primary outcomes of interest (patient-reported pain relief of 30%, or 50%, or greater).
The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Nutrients (2025) · Rct · n=30
Results: A significant time effect was observed in the MoCA score, which was mainly explained by a significant increase in the 5-HTP group (week 0 vs. week 12: 26.6 ± 1.4 a.u. vs. 27.6 ± 1.4 a.u., p < 0.05).
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
Nutrients (2021) · Systematic review
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states.
Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review
Nutrients (2020) · Systematic review
Passiflora incarnata may be helpful in treating some symptoms in neuropsychiatric patients.
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
Limited evidence from small RCTs (n=30, n=166). Effectiveness constrained by mixed study populations and preliminary findings. Higher doses associated with increased nausea risk.
Based on meta-analysis of 198 subjects noting insufficient RCT data for definitive conclusions. Effectiveness limited by small sample sizes and study quality limitations. Drowsiness is primary dose-limiting side effect.
AI-estimated from published studies. Interpret as directional guidance.
5-HTP has a higher evidence score (8.5/10 vs 8/10) and wins in 2 of 3 categories.
For reduce anxiety & stress, Passionflower has a higher relevance score (85 vs 60).
No known interactions between 5-HTP and Passionflower have been documented in our database. However, always consult a healthcare provider before combining supplements.