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Head-to-head evidence comparison — which supplement is right for you?
Modafinil wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Adrafinil (Olmifon) and Modafinil have evidence — compare verdict strength side-by-side.
Historically Olmifon was dosed around 600–1200 mg/day (in divided doses, earlier in the day) — roughly 3–4× a modafinil dose because of incomplete hepatic conversion. There is no approved or standardized regimen today; it is an unapproved grey-market chemical and not a clinician-supervised drug.
morning
Oral capsule/powder (grey-market; no approved product)
Approved dosing is 200 mg once daily in the morning for narcolepsy and OSA, or 200 mg taken ~1 hour before the start of a night shift for shift-work sleep disorder. A prescription drug; off-label cognitive use is not an approved or standardized regimen.
morning
Oral tablet (modafinil)
Hours (per dose, after hepatic conversion)
Per dose; effect persists over repeated dosing
Acute
Chronic use
Hours (per dose); weeks for steady benefit
Per dose (acute)
Acute
Throughout use
Modafinil: its discovery, the early European and North American experience in the treatment of narcolepsy and idiopathic hypersomnia, and its subsequent use in other medical conditions.
Sleep medicine (2018) · Review
Historical review tracing adrafinil (identified by Lafon in 1974) and the discovery of its active metabolite, modafinil
Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects.
Substance abuse (2020) · Review
Pharmacokinetic/pharmacodynamic review that frames adrafinil explicitly as the prodrug of modafinil
Oral administration of adrafinil improves discrimination learning in aged beagle dogs.
Pharmacology, biochemistry, and behavior (2000) · Animal
Aged beagle dogs trained on size or intensity discrimination 2 h after 20 mg/kg adrafinil or placebo (counterbalanced crossover)
Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. US Modafinil in Narcolepsy Multicenter Study Group.
Annals of neurology (1998) · Rct · n=283
Pivotal placebo-controlled, double-blind, 18-center RCT in 283 narcolepsy patients (modafinil 200 or 400 mg vs placebo)
Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group.
Neurology (2000) · Rct · n=271
Second pivotal 9-week, placebo-controlled, double-blind, 21-center RCT (n=271; 200 or 400 mg vs placebo)
Modafinil for excessive sleepiness associated with shift-work sleep disorder.
The New England journal of medicine (2005) · Rct · n=209
3-month double-blind RCT of 200 mg modafinil before each night shift vs placebo in 209 shift-work-sleep-disorder patients (NEJM)
Modafinil has a higher evidence score (5/10 vs 3.4/10) and wins in 2 of 3 categories.
No known interactions between Adrafinil (Olmifon) and Modafinil have been documented in our database. However, always consult a healthcare provider before combining supplements.