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Head-to-head evidence comparison — which supplement is right for you?
Shiitake wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
4 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
3 of 5 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Andrographis and Shiitake have evidence — compare verdict strength side-by-side.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
5-15g dried mushroom or 1-3g extract daily
With meals, Divided doses if using higher amounts
Shiitake extract (standardized to polysaccharides)
2-5 days
2-5 days
2-5 days
4 weeks
8-12 weeks
4-8 weeks
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis · n=1000
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Critical Review on the Anti-Tumor Activity of Bioactive Compounds from Edible and Medicinal Mushrooms over the Last Five Years
Nutrients (2025) · Systematic review
In recent years, the incidence rate of cancer has been on the rise all over the world, and the age of cancer patients has shown a younger trend, which seriously endangers patients' health.
Vitamin B12 sources in non-animal foods: a systematic review
Critical reviews in food science and nutrition (2023) · Systematic review · n=25
In the last decade, more sensitive method for real B12 determination was used, the liquid chromatography-electrospray ionization tandem mass spectrometry chromatograms.
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
International journal of molecular sciences (2023) · Systematic review
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
Based on RCT showing significant improvement in cough (SMD -0.39) and sore throat symptoms. Conservative effectiveness estimates due to moderate effect sizes in meta-analysis of respiratory infections.
Based on beta-glucan studies and one pilot RCT (n=239) showing modest immune response trends. Evidence limited by small sample sizes and primarily preclinical data. Effects may vary significantly by extract standardization and processing method.
AI-estimated from published studies. Interpret as directional guidance.
Shiitake has a higher evidence score (4.5/10 vs 7/10) and wins in 2 of 3 categories.
For support immune system, Andrographis has a higher relevance score (90 vs 75).
No known interactions between Andrographis and Shiitake have been documented in our database. However, always consult a healthcare provider before combining supplements.