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Head-to-head evidence comparison — which supplement is right for you?
Andrographis vs Vitamin E: they're closely matched on evidence (7 vs 5/10); they're alternatives for inflammation-related symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Andrographis and Vitamin E are closely matched across evidence, studies, and safety.
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
10 of 10 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Andrographis and Vitamin E have evidence — compare verdict strength side-by-side.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
100-400 IU daily (natural d-alpha-tocopherol)
With fat-containing meal, Any time of day
Natural mixed tocopherols (d-alpha, beta, gamma, delta)
2-5 days
2-5 days
2-5 days
4-8 weeks
4-8 weeks
8-12 weeks
With high doses
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Effect of vitamin B(2), vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
BMJ open (2024) · Meta analysis · n=2218
Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo.
The Effect of Vitamin E Supplementation on Serum Aminotransferases in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis
Nutrients (2023) · Meta analysis · n=794
A total of 794 patients from 12 randomized trials were included in this meta-analysis.
Vitamin E supplementation in pregnancy
The Cochrane database of systematic reviews (2015) · Meta analysis · n=22129
Twenty-one trials, involving 22,129 women were eligible for this review. All of the 17 trials contributing data assessed vitamin E in combination with vitamin C and/or other agents.
Two placebo-controlled trials of the same standardised extract (KalmCold, also sold as AP-Bio). At 200 mg a day, 223 adults with an uncomplicated upper respiratory infection had lower overall symptom scores than placebo by day 5 (PMID 20092985). In a 300-person trial of 200 or 400 mg a day for 7 days, both doses lowered symptom scores on day 3 by the same amount, with no difference on days 5 and 7, and no participant reported adverse physical symptoms (PMID 36842634). 400 mg was no better than 200 mg, so the curve is flat and no optimal dose is given. The respiratory infection meta-analysis (PMID 28783743) reports symptom benefits but no doses, so it is not plotted.
AI-estimated from published studies. Interpret as directional guidance.
Both Andrographis and Vitamin E are closely matched — the best choice depends on your specific health goals.
For inflammation-related symptoms, Andrographis has a higher relevance score (70 vs 60).
No known interactions between Andrographis and Vitamin E have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.