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Head-to-head evidence comparison — which supplement is right for you?
Artichoke Extract vs Vitamin B12: Vitamin B12 has the stronger overall evidence (7.5 vs 7/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Vitamin B12 wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
8 of 9 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
16 of 23 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Artichoke Extract and Vitamin B12 have evidence — compare verdict strength side-by-side.
600-1200mg extract daily
Before meals (especially fatty meals), Divided doses
Standardized leaf extract (2.5-5% cynarin)
500-1000mcg daily for maintenance; higher for deficiency
Morning (may be energizing), With or without food
Methylcobalamin (sublingual)
2-4 weeks
8-12 weeks
4-8 weeks
2-4 weeks
4-8 weeks
Weeks to months
Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
Critical reviews in food science and nutrition (2018) · Meta analysis · n=702
Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics.
Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
Nutrients (2024) · Systematic review
This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases.
The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. Part II
Phytotherapy research : PTR (2024) · Systematic review
The available evidence showed promising hypoglycemic effects of the nutraceuticals reviewed both for their efficacy and safety profile.
Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Irish journal of medical science (2024) · Meta analysis · n=4275
Regarding the hemoglobin level, the pooled effect sizes showed no difference between all routes of administration that could reach statistical significance.
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Vitamin Status in Patients with Phenylketonuria: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2024) · Meta analysis · n=770
The effect sizes were expressed as standardised mean differences.
Based on meta-analysis of 702 subjects showing 17.6 mg/dL reduction in total cholesterol. Effect size is modest and may require 6+ weeks to manifest. Limited to artichoke leaf extract studies.
AI-estimated from published studies. Interpret as directional guidance.
Vitamin B12 has a higher evidence score (7.5/10 vs 7/10) and wins in 1 of 3 categories.
No known interactions between Artichoke Extract and Vitamin B12 have been documented in our database. However, always consult a healthcare provider before combining supplements.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.