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Head-to-head evidence comparison — which supplement is right for you?
Ginkgo Biloba vs Phosphatidylserine: Ginkgo Biloba has the stronger overall evidence (7 vs 6/10); they're alternatives for improve memory & learning — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Ginkgo Biloba wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
5 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (2)
Outcomes where both Ginkgo Biloba and Phosphatidylserine have evidence — compare verdict strength side-by-side.
120-240mg standardized extract
With meals, Split into 2-3 doses
Standardized extract capsules (EGb 761)
100-300mg daily
With meals, Evening or post-workout for cortisol
Soy or sunflower-derived phosphatidylserine
12-24 weeks
8-12 weeks
First week
4-12 weeks
2 weeks
4-8 weeks
Can We Use Ginkgo biloba Extract to Treat Alzheimer's Disease? Lessons from Preclinical and Clinical Studies
Cells (2022) · Meta analysis · n=2100
GBE was shown to reduce the escape latencies in several studies, in both rats and mice (I2 > 70%, p < 0.005).
Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials
Phytotherapy research : PTR (2022) · Meta analysis · n=1104
In the meta-analysis, the weighted mean differences (WMD) in change for serum CRP were -1.5 mg/L (95% CI: -2.16, -0.85, p < 0.001).
Miscellaneous treatments for antipsychotic-induced tardive dyskinesia
The Cochrane database of systematic reviews (2018) · Meta analysis · n=1278
Studies were primarily of short (three to six6 weeks) duration with small samples size (10 to 157 participants), and most (61%) were published more than 20 years ago.
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
Journal of affective disorders (2025) · Rct · n=190
The capsule combined phosphatidylserine (63 mg/day) with α-linolenic acid, ginkgo flavonoids, vitamins B1 and B6 and folic acid, taken for 12 months. The effect cannot be credited to phosphatidylserine alone.
Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
Dementia and geriatric cognitive disorders (2010) · Rct · n=157
157 participants were randomized to receive either PS-DHA or placebo for 15 weeks.
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
Journal of alternative and complementary medicine (2021) · Meta analysis · n=216
Four studies met the inclusion criteria for the narrative review (n = 344) and three for the meta-analysis (n = 216).
The trials behind these points gave 120 or 240 mg of the standardised extract EGb 761 daily to people with dementia for about 6 months (PMID 25506211, 7 trials, 2,625 patients). A meta-analysis of 9 trials found the benefits on cognition, daily activities and global impression mainly at 240 mg (PMID 25114079), and one of mild dementia subgroups found medium to large effects at 240 mg (PMID 39895346). A network meta-analysis of trials lasting over a year ranked 120 mg best for cognition in Alzheimer's disease (PMID 39312316), so 120 mg is plotted as effective, not null. Adverse events matched placebo at both doses. The Cochrane review rates the dementia benefit small to moderate and low certainty, and found little or no effect in mild cognitive impairment (PMID 41641880). In older people with normal cognition, 240 mg a day for about 6 years did not prevent dementia (PMID 19017911). No cited trial tested more than 240 mg.
The dose points come from one randomised, double-blind trial of 78 Japanese adults aged 50 to 69 with memory complaints (PMID 21103034), who took 100 mg or 300 mg a day of soy-derived phosphatidylserine or placebo for 6 months. Test scores rose similarly in all groups, placebo included, so neither dose is shown to beat placebo. Memory scores rose from baseline on both doses only in people with low baseline scores, a within-group result. No side effects and no change in blood markers were seen, which is why the ceiling is 300 mg. The PS-DHA memory trial (PMID 20523044, 157 older adults) states no dose, the 190-person trial in mild cognitive impairment (PMID 39317299) gave 63 mg inside a multi-ingredient capsule, and the pooled 200 to 300 mg effect on inattention (PMID 33539192) is in children with ADHD, so none of them can sit on this curve.
AI-estimated from published studies. Interpret as directional guidance.
Ginkgo Biloba has a higher evidence score (7/10 vs 6/10) and wins in 2 of 3 categories.
For improve memory & learning, Phosphatidylserine has a higher relevance score (80 vs 70).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.