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Head-to-head evidence comparison — which supplement is right for you?
Iodine vs Turkey Tail: Iodine has the stronger overall evidence (8.5 vs 6/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Iodine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Limited support
1 of 4 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
150-300mcg for maintenance; higher only if deficient under supervision
Any time with food
Potassium iodide (most common and studied)
1-3g dried mushroom or equivalent extract
With or without food
Hot water extract capsules or powder
and 2 more not shown
4-12 weeks
4-8 weeks
4-8 weeks
4-8 weeks
Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis
Nutrients (2023) · Meta analysis · n=42269
Birth weight was similar between UIC ≥ 150 μg/L and <150 μg/L (difference = 30 g, 95% CI −22 to 83, p = 0.3, n = 13, I2 = 89%) with no evidence of linear trend (4 g per 50 μg/L, −3 to 10, p = 0.2, n = 12, I2 = 80%).
Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders
The Cochrane database of systematic reviews (2019) · Meta analysis · n=4317
This is equivalent to an increase of 38.32 µg/L (95% CI 24.03 to 52.61 µg/L).
Systematic review and meta-analysis of iodine nutrition in modern vegan and vegetarian diets
The British journal of nutrition (2023) · Meta analysis · n=4421
Vegan diets had the poorest iodine intake (17·3 µg/d) and were strongly associated with lower iodine intake (P = < 0·001) compared with omnivorous diets.
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
International journal of molecular sciences (2023) · Review
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer
The Cochrane database of systematic reviews (2022) · Systematic review · n=1569
We found low-certainty evidence of a small effect of adjunctive Coriolus on improved survival at five years compared with no adjunctive care (RR 1.08, 95% CI 1.01 to 1.15; 1094 participants; 3 studies; number needed to benefit (NNTB) = 16 (95% Cl 9 to 70).
Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms
Nutrients (2022) · Review
Our review summarizes the research progress on the anticancer properties of edible and medicinal fungi and the underlying molecular mechanism, which may offer a better understanding of this field.
The only cited trial that compared doses is a phase I dose-escalation study with no control group (PMID 22701186): women who had finished radiotherapy for breast cancer took 3, 6 or 9 g a day of a Trametes versicolor preparation for 6 weeks, 3 women per dose, 9 completing. It reported trends, not significant effects: higher lymphocyte counts at 6 and 9 g, higher natural killer cell activity at 6 g, and dose-related rises in CD8+ T cells and CD19+ B cells. Nine adverse events were reported (7 mild, 1 moderate, 1 severe) and the authors judged up to 9 g a day safe and tolerable. These are blood immune markers, not infections or other clinical outcomes, and no trial shows a benefit above 6 g.
AI-estimated from published studies. Interpret as directional guidance.
Iodine has a higher evidence score (8.5/10 vs 6/10) and wins in 2 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
Selenium helps; iodine can WORSEN Hashimoto’s. The honest take on "thyroid support".
What’s safe while nursing, the truth about milk-supply herbs, and what to avoid (it passes into milk).
Commonly recommended vs ask-your-clinician vs avoid — a general, safety-first overview.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.