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Head-to-head evidence comparison — which supplement is right for you?
Spearmint vs Vitex: Vitex has the stronger overall evidence (7 vs 6.2/10); they're alternatives for testosterone & cortisol symptoms — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Vitex wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
11 of 12 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Spearmint and Vitex have evidence — compare verdict strength side-by-side.
900 mg/day of standardized spearmint extract (or 2 cups of spearmint herbal tea daily)
Morning with breakfast, Evening with dinner (split dosing mirrors clinical trial protocols)
Standardized aqueous extract (high-rosmarinic acid)
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
and 1 more not shown
2–4 weeks
4–12 weeks
4–8 weeks
8–16 weeks
1-3 cycles
2-3 cycles
1-2 cycles
An evidence-based systematic review of spearmint by the natural standard research collaboration.
Journal of dietary supplements (2010) · Systematic review
Spearmint (Mentha spicata) has demonstrated anti-androgenic, antimicrobial, and antioxidant properties in available literature.
A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (2020) · Systematic review
Spearmint syrup was identified as one of several herbal alternatives showing efficacy for mild-to-moderate pregnancy nausea and vomiting.
Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial.
Phytotherapy research : PTR (2010) · Rct · n=42
Forty-one of 42 patients completed this 30-day RCT comparing spearmint tea twice daily to placebo herbal tea.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Meta analysis
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Based on 2 RCTs in women with PCOS/hirsutism. Tea form equivalent to ~400-600mg extract. Effects specific to women; men should avoid chronic high-dose use.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
Vitex has a higher evidence score (7/10 vs 6.2/10) and wins in 2 of 3 categories.
For testosterone & cortisol symptoms, Vitex has a higher relevance score (92 vs 85).
No known interactions between Spearmint and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.