Supplements for Male Fertility

A lipid-soluble antioxidant central to mitochondrial energy production, with the strongest trial support for fertility/IVF outcomes and heart failure.

Increase sperm concentration by ~5.9 million/mL· Weak evidence

Rate-limiting precursor to glutathione, the body's master antioxidant — supports mood, respiratory health, and liver protection.

Increase sperm concentration by ~3.8 million/mL· Weak evidence

Andean root with modest evidence for improving sexual desire — small RCTs are encouraging but reviews still rate the overall evidence as limited.

Raises sperm concentration by ~4.9 M/mL· Weak evidence

Required for selenoprotein production that regulates thyroid hormones, powers glutathione peroxidase, and strengthens immune defense.

Raises sperm concentration by ~3.9 M/mL· Weak evidence

Acetylated carnitine that crosses the blood-brain barrier to fuel mitochondrial energy and donate acetyl groups for acetylcholine synthesis.

Weak evidence

Saponin-rich herb that consistently improves libido and sexual function, though evidence for testosterone elevation remains weak.

Weak evidence

Bioactive folate that bypasses MTHFR conversion — critical for the 30-40% of people with gene variants affecting mood and methylation.

Widely studied for PCOS-related insulin sensitivity and ovulatory function; also studied for anxiety and mood.

Universal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.

Essential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.