5-HTP and St. John's Wort: Can You Take Them Together?

Use caution — significant interaction

5-HTP and St. John's Wort can interact. Risk of serotonin syndrome Do not combine without medical supervision

What the evidence says

majorconflict· moderate evidence

Risk of serotonin syndrome

Additive serotonergic activity — a direct serotonin precursor combined with reuptake inhibition

What to do: Do not combine without medical supervision

5-HTP

Evidence, dosage & safety →

St. John's Wort

Evidence, dosage & safety →

Compare 5-HTP vs St. John's Wort Check your full stack

Related interactions

5-HTP & Trazodone 5-HTP & Melatonin St. John's Wort & Trazodone St. John's Wort & Tryptophan St. John's Wort & Vitamin D3

Frequently asked questions

Can you take 5-HTP and St. John's Wort together?: 5-HTP and St. John's Wort can interact. Risk of serotonin syndrome Do not combine without medical supervision
Do 5-HTP and St. John's Wort interact?: Risk of serotonin syndrome Additive serotonergic activity — a direct serotonin precursor combined with reuptake inhibition
Should you separate 5-HTP and St. John's Wort?: Do not combine without medical supervision

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.