Peter Diamandis — maximalist longevity stack

A maximalist “address every hallmark of aging” regimen — by his own account ~75 pills a day, adjusted off quarterly bloodwork — spanning aggressive lipid lowering, rapamycin, TRT, NAD precursors and a broad antioxidant layer. The notable items are below. COI: he co-founded Lifeforce / Fountain Life (diagnostics + supplements). Documented as reported, not endorsed.

Peter Diamandis, MD is an entrepreneur and physician, founder of the XPRIZE Foundation and co-founder of Singularity University, Fountain Life and Lifeforce, and author of The Longevity Guidebook.

Website ↗Wikipedia ↗

Photo: XPRIZE Foundation / CC BY 2.0, via Wikimedia Commons

Documented, not endorsed. What Peter Diamandis, MD reports taking (as of 2026-06) — not medical advice, not a recommendation. We sell nothing; each item links to its independently evidence-graded card.

At a glance

Aimed at (inferred from 22 mapped members)

🧬 Longevity & healthspan 16💪 Performance & recovery 8😌 Mood & stress 7🫀 Cardiovascular 3⚖️ Metabolic & weight 3🌙 Sleep 2

Evidence makeup

6 Strong 8 Moderate 3 Emerging 5 Gated / research compound

5 of 22 mapped items are gated research compounds — informational only.

The stack · 22 compounds

Core

⏳ Rapamycinresearch compound
mTOR-inhibition geroprotector — experimental.
Emerging 4.5~6 mg weekly · weekly, off-label
🩸 Rosuvastatin (Crestor)research compound
Aggressive ApoB/LDL lowering.
Emerging 4.5no dose info (Crestor)
🩸 Ezetimibe (Zetia)research compound
Cholesterol-absorption inhibitor added to the statin.
Emerging 4.4no dose info (Zetia)
⏳ NMN
NAD+ precursor.
Moderate 5.5no dose info
🐟 Omega-3
Cardiovascular / anti-inflammatory foundation.
Strong 9.0no dose info
☀️ Vitamin D3
Foundational micronutrient.
Moderate 7.5no dose info
✨ Magnesium
Foundational mineral.
Strong 8.5no dose info (glycinate)
⚡ B-Complex
Methylation / B-vitamin support.
Moderate 6.5no dose info
⚡ Creatine
Muscle and ATP support.
Strong 9.5no dose info
💫 Taurine
Longevity-associated amino acid.
Moderate 7.52,000 mg

Situational

🩸 Evolocumab (Repatha)research compound
PCSK9 inhibitor for the most aggressive ApoB targets.
Emerging 4.5no dose info (Repatha)
⚧️ Testosterone (TRT)research compound
Hormone optimization (TRT).
Moderate 5.6no dose info
⚡ CoQ10
Mitochondrial / cardiovascular.
Strong 8.0100 mg (with PQQ 10 mg)
🔋 PQQ
Mitochondrial biogenesis (paired with CoQ10).
Emerging 4.510 mg
🛡️ Glutathione
Master antioxidant.
Emerging 4.8no dose info
⚡ Alpha Lipoic Acid
Antioxidant / mitochondrial.
Moderate 7.0no dose info
🍊 Vitamin C
Antioxidant.
Strong 8.0no dose info (liposomal)
🦐 Astaxanthin
Antioxidant.
Moderate 5.0no dose info
🌿 Curcumin
Anti-inflammatory.
Moderate 7.5no dose info (Metacurcumin)
⚡ DHEA
Hormone-precursor support.
Moderate 5.5no dose info (with pregnenolone)
🔄 Pregnenolone
Hormone-precursor support.
Emerging 4.5no dose info
🦠 Probiotics
Gut health.
Strong 9.0no dose info

“no dose info” = publicly known to take it, but no reliable dose has been stated.

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“Start” adds the 17 evidence-graded compounds to your own stack to edit — gated research compounds excluded. Not an endorsement.

Synergies (5)

CoQ10 + Omega-3 — Taking CoQ10 with fats increases absorption by 3-5x
Omega-3 + Curcumin — Synergistic anti-inflammatory effects through complementary mechanisms
Vitamin D3 + Magnesium — Magnesium deficiency impairs vitamin D metabolism and effectiveness
Magnesium + Taurine — Enhanced magnesium utilization and cellular availability
CoQ10 + PQQ — Enhanced mitochondrial quantity and quality

Documented supplement–supplement interactions between members of this stack — not a personal interaction check. Full interaction checker →

Compare with another stack

All comparisons →

Sources: The Longevity Guidebook & diamandis.com · Published personal supplement list (2024)