Best Supplements for Estrogen & Progesterone Balance

Reduces cortisol and anxiety while improving sleep quality and physical recovery in stressed adults.

Raises serum testosterone by ~78.2 ng/dL· Weak evidence

Enhances insulin signaling to improve glucose uptake into cells — helps regulate blood sugar and reduce carbohydrate cravings.

Boosts total testosterone by ~54 ng/dL· Weak evidence

Traditional herb with evidence for supporting testosterone, libido, blood sugar control, and lactation.

Boosts total testosterone by ~48 ng/dL· Weak evidence

Saponin-rich herb that consistently improves libido and sexual function, though evidence for testosterone elevation remains weak.

Weak evidence

Adrenal hormone precursor that declines with age, supporting hormone balance, energy, and body composition.

Weak evidence

Rate-limiting precursor to glutathione, the body's master antioxidant — supports mood, respiratory health, and liver protection.

Weak evidence

Shifts estrogen metabolism toward beneficial 2-hydroxy metabolites, reducing harmful estrogen dominance in both men and women.

Preliminary evidence

Involved in 300+ enzymatic reactions — supports immune defense, testosterone production, wound healing, and sleep quality.

Preliminary evidence

Enhances mitochondrial energy production and acts as a lipid-soluble antioxidant — critical for heart health and depleted by statins.

Weak evidence

First-line natural treatment for PCOS that improves insulin sensitivity and ovulation — also reduces anxiety, panic, and OCD symptoms.

Weak evidence