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Head-to-head evidence comparison — which supplement is right for you?
DHEA vs Vitex: they're closely matched on evidence (5.5 vs 7/10); they're alternatives for testosterone & cortisol balance — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
DHEA and Vitex are closely matched across evidence, studies, and safety.
Verdict
Probably helps
4 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
11 of 12 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both DHEA and Vitex have evidence — compare verdict strength side-by-side.
25-50mg for women; 50-100mg for men (start low)
Morning (mimics natural rhythm)
Micronized DHEA capsules
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
and 1 more not shown
4-8 weeks
8-12 weeks
1-3 cycles
2-3 cycles
1-2 cycles
Dehydroepiandrosterone for depressive symptoms: A systematic review and meta-analysis of randomized controlled trials
Journal of neuroscience research (2020) · Meta analysis · n=742
No hormonal changes that indicated any risk to the participants' health were seen.
Hormonal Treatments and Vaginal Moisturizers for Genitourinary Syndrome of Menopause : A Systematic Review
Annals of internal medicine (2024) · Systematic review
Vaginal estrogen, vaginal DHEA, oral ospemifene, and vaginal moisturizers may improve some GSM symptoms in the short term.
TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis
Reproductive biology and endocrinology : RB&E (2023) · Meta analysis · n=2323
Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Meta analysis
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Based on meta-analysis showing OR 1.92 for clinical pregnancy rate in poor ovarian response patients. Effect specific to fertility treatment context with medical supervision. Limited long-term safety data.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
Both DHEA and Vitex are closely matched — the best choice depends on your specific health goals.
For testosterone & cortisol balance, Vitex has a higher relevance score (92 vs 72).
No known interactions between DHEA and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.
Mostly hype unless you’re deficient — what has modest evidence vs what doesn’t, and when to see a doctor.
The transition years (40s): cycle changes, mood, sleep, brain fog — foundations, vitex, and starting muscle work early.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.