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Head-to-head evidence comparison — which supplement is right for you?
Iodine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mixed evidence
4 of 12 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Iodine and Tyrosine have evidence — compare verdict strength side-by-side.
150-300mcg for maintenance; higher only if deficient under supervision
Any time with food
Potassium iodide (most common and studied)
500-2000mg
30-60 minutes before stressful activity, On empty stomach for best absorption
L-Tyrosine powder or capsules
4-12 weeks
4-8 weeks
30-60 minutes
30-60 minutes
30-60 minutes
Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis
Nutrients (2023) · Meta analysis · n=42269
Birth weight was similar between UIC ≥ 150 μg/L and <150 μg/L (difference = 30 g, 95% CI −22 to 83, p = 0.3, n = 13, I2 = 89%) with no evidence of linear trend (4 g per 50 μg/L, −3 to 10, p = 0.2, n = 12, I2 = 80%).
Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders
The Cochrane database of systematic reviews (2019) · Meta analysis · n=4317
This is equivalent to an increase of 38.32 µg/L (95% CI 24.03 to 52.61 µg/L).
Systematic review and meta-analysis of iodine nutrition in modern vegan and vegetarian diets
The British journal of nutrition (2023) · Meta analysis · n=4421
Vegan diets had the poorest iodine intake (17·3 µg/d) and were strongly associated with lower iodine intake (P = < 0·001) compared with omnivorous diets.
Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance
Neuropsychologia (2015) · Rct · n=22
Tyrosine supplementation improved task switching performance under demanding conditions
Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands: A review
Journal of Psychiatric Research (2015) · Review
Converging evidence for cognitive enhancement under demanding conditions
Based on meta-analyses showing urinary iodine concentration increases with supplementation. Effects only meaningful in iodine-deficient populations. Excessive intake (>300mcg) may increase thyroid cancer risk. Most studies used potassium iodide; kelp-derived forms have variable bioavailability.
Based on single meta-analysis of 56 participants showing significantly higher blood tyrosine concentrations with supplementation. Clinical significance of elevated blood tyrosine levels for cognitive outcomes remains unclear. Most claimed cognitive effects lack direct study support in the provided evidence.
AI-estimated from published studies. Interpret as directional guidance.
Iodine has a higher evidence score (8.5/10 vs 6/10) and wins in 2 of 3 categories.
For boost daily energy, Iodine has a higher relevance score (95 vs 60).
No known interactions between Iodine and Tyrosine have been documented in our database. However, always consult a healthcare provider before combining supplements.