Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Melatonin wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
19 of 24 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Lavender and Melatonin have evidence — compare verdict strength side-by-side.
80 mg oral Silexan daily OR aromatherapy inhalation 30–60 min sessions
Evening before bed for sleep and anxiety, Acute use before stressful procedures or events
Oral Silexan capsule (80 mg) for systemic/psychiatric use
0.5-1mg
30-60 minutes before bed
Immediate-release tablet or sublingual
1–4 weeks
1–3 weeks
4–8 weeks
Acute to 2 weeks
Same night
1-3 days
Next morning
First week
Effects of lavender on anxiety: A systematic review and meta-analysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology (2019) · Meta analysis
Meta-analysis confirmed significant anxiolytic effects of lavender across multiple administration routes
Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.
European archives of psychiatry and clinical neuroscience (2023) · Meta analysis
Silexan 80 mg/day was significantly superior to placebo in reducing Hamilton Anxiety Rating Scale (HAMA) total scores
Efficacy of Silexan in subthreshold anxiety: meta-analysis of randomised, placebo-controlled trials.
European archives of psychiatry and clinical neuroscience (2019) · Meta analysis
Silexan 80 mg/day significantly reduced HAMA scores compared to placebo in subthreshold anxiety
Melatonin in cancer treatment
The Cochrane database of systematic reviews (2025) · Meta analysis · n=126
We downgraded the certainty of the evidence because of high risk of bias, small sample size, the width of the 95% confidence interval, and indirectness due to inadequate reporting of cancer type.
Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis
Journal of Alzheimer's disease : JAD (2024) · Meta analysis · n=4599
Melatonin may be a better potential disease-modifying treatment for cognitive decline in mild AD and MCI.
Melatonin for sleep disorders in people with autism: Systematic review and meta-analysis
Progress in neuro-psychopharmacology & biological psychiatry (2023) · Meta analysis · n=595
According to the global analysis, the wake after sleep onset and night awakening parameters were not statistically significant.
Based on meta-analyses showing 7-12 minute reduction in sleep onset. Higher doses showed diminishing returns and increased morning grogginess. Sublingual forms may be more effective at lower doses.
AI-estimated from published studies. Interpret as directional guidance.
Melatonin has a higher evidence score (8.5/10 vs 7.2/10) and wins in 1 of 3 categories.
For fall asleep faster, Melatonin has a higher relevance score (95 vs 70).
No known interactions between Lavender and Melatonin have been documented in our database. However, always consult a healthcare provider before combining supplements.