Mark Hyman — functional-medicine stack

The functional-medicine figure’s reported regimen. SEVERE COI: his most-cited "personal stack" is literally a 13-product bundle he sells, and he co-founded Function Health (the test-and-sell loop). Doses are product-label, not spoken figures. Documented by underlying compound, not endorsed. He does not take metformin or rapamycin.

Mark Adam Hyman is an American physician and author . He is the founder and medical director of The UltraWellness Center.

Website ↗Wikipedia ↗

Photo: Stephanie Williams / CC BY-SA 4.0, via Wikimedia Commons

Documented, not endorsed. What Mark Hyman, MD reports taking (as of 2026-06) — not medical advice, not a recommendation. We sell nothing; each item links to its independently evidence-graded card.

At a glance

Aimed at (inferred from 15 mapped members)

🧬 Longevity & healthspan 13😌 Mood & stress 5💪 Performance & recovery 4🧠 Cognition 2

Evidence makeup

4 Strong 9 Moderate 2 Emerging

The stack · 15 compounds

Core

🐟 Omega-3
Foundational.
Strong 9.0no dose info (daily fish oil)
☀️ Vitamin D3
Deficiency/immune.
Moderate 7.55,000 IU + K1/K2
💊 Multivitamin
Gaps + his congenital high homocysteine.
Moderate 6.0no dose info (B-heavy)
🛡️ NAC
Glutathione support — his "most important thing I do daily."
Moderate 6.0no dose info
⚡ Creatine
Muscle/cognition/aging.
Strong 9.5no dose info (uses daily)
🍇 Urolithin A
Mitophagy — one of his clearest first-person items.
Moderate 6.0250 mg

Situational

⚡ Alpha Lipoic Acid
Antioxidant / glutathione support.
Moderate 7.0no dose info
🛡️ Glutathione
Detox (he reports poor GSTM1 detox).
Emerging 4.8no dose info
⏳ NMN
NAD+ (affiliated brand).
Moderate 5.5900 mg
⚡ CoQ10
Mitochondrial.
Strong 8.0~200 mg
🌿 Curcumin
Inflammation.
Moderate 7.5~500–700 mg
🦠 Probiotics
Gut/microbiome.
Strong 9.0no dose info (sponsor brand)
🍎 Quercetin
Senolytic.
Moderate 6.0no dose info (bundled, cycled)
🍓 Fisetin
Senolytic.
Emerging 3.5100 mg (cycled)
💪 TMG
Homocysteine / methylation.
Moderate 5.8no dose info

“no dose info” = publicly known to take it, but no reliable dose has been stated.

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“Start” adds the 15 evidence-graded compounds to your own stack to edit — gated research compounds excluded. Not an endorsement.

Watch-outs (1)

Multivitamin ✕ Vitamin D3 — Combined D3 intake above 4000 IU/day long-term increases risk of hypercalcemia, hypercalciuria, kidney stone formation, and vascular calcification. The effect is amplified when calcium intake is also high. Quantify total vitamin D from all supplements. If using standalone D3, choose a product accounting for multivitamin D3 content. Monitor serum 25(OH)D; maintain 40–60 ng/mL as optimal range. Avoid exceeding 4000 IU/day without medical supervision and confirmed 25(OH)D testing.

Synergies (2)

CoQ10 + Omega-3 — Taking CoQ10 with fats increases absorption by 3-5x
Omega-3 + Curcumin — Synergistic anti-inflammatory effects through complementary mechanisms

Documented supplement–supplement interactions between members of this stack — not a personal interaction check. Full interaction checker →

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Sources: “Mark’s Personal Stack” & first-person statements