Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Phosphatidylserine vs Tyrosine: they're closely matched on evidence (6 vs 6/10); they're alternatives for sharpen focus — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Phosphatidylserine and Tyrosine are closely matched across evidence, studies, and safety.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Phosphatidylserine and Tyrosine have evidence — compare verdict strength side-by-side.
100-300mg daily
With meals, Evening or post-workout for cortisol
Soy or sunflower-derived phosphatidylserine
500-2000mg (a typical label dose, not the dose used in the cited trials, which used 2 g five times a day for a week, or a single 100 mg per kg dose)
30-60 minutes before stressful activity, On empty stomach for best absorption
L-Tyrosine powder or capsules
4-12 weeks
2 weeks
4-8 weeks
30-60 minutes
30-60 minutes
30-60 minutes
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
Journal of affective disorders (2025) · Rct · n=190
The capsule combined phosphatidylserine (63 mg/day) with α-linolenic acid, ginkgo flavonoids, vitamins B1 and B6 and folic acid, taken for 12 months. The effect cannot be credited to phosphatidylserine alone.
Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
Dementia and geriatric cognitive disorders (2010) · Rct · n=157
157 participants were randomized to receive either PS-DHA or placebo for 15 weeks.
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
Journal of alternative and complementary medicine (2021) · Meta analysis · n=216
Four studies met the inclusion criteria for the narrative review (n = 344) and three for the meta-analysis (n = 216).
Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance
Neuropsychologia (2015) · Rct · n=22
Tyrosine supplementation improved task switching performance under demanding conditions
Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands: A review
Journal of Psychiatric Research (2015) · Review
Converging evidence for cognitive enhancement under demanding conditions
The effect of tyrosine supplementation on whole-body endurance performance in physically active population: A systematic review and meta-analysis including GRADE qualification.
Journal of sports sciences (2023) · Meta analysis
No significant difference vs placebo for time to exhaustion (SMD = 0.02; p = 0.94)
The dose points come from one randomised, double-blind trial of 78 Japanese adults aged 50 to 69 with memory complaints (PMID 21103034), who took 100 mg or 300 mg a day of soy-derived phosphatidylserine or placebo for 6 months. Test scores rose similarly in all groups, placebo included, so neither dose is shown to beat placebo. Memory scores rose from baseline on both doses only in people with low baseline scores, a within-group result. No side effects and no change in blood markers were seen, which is why the ceiling is 300 mg. The PS-DHA memory trial (PMID 20523044, 157 older adults) states no dose, the 190-person trial in mild cognitive impairment (PMID 39317299) gave 63 mg inside a multi-ingredient capsule, and the pooled 200 to 300 mg effect on inattention (PMID 33539192) is in children with ADHD, so none of them can sit on this curve.
AI-estimated from published studies. Interpret as directional guidance.
Both Phosphatidylserine and Tyrosine are closely matched — the best choice depends on your specific health goals.
For sharpen focus, Tyrosine has a higher relevance score (80 vs 60).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
Caffeine+L-theanine works; bacopa needs weeks; most "brain pills" are hype. The honest tier list.
Selenium helps; iodine can WORSEN Hashimoto’s. The honest take on "thyroid support".
Caffeine, citrulline, beta-alanine, creatine — the ingredients that work, at clinical doses (vs fairy dusting).
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.